Liquid nucleotides/nucleosides-containing product

Abstract

The invention pertains to a liquid composition for preventing and/or treating memory decline and/or cognitive dysfunction, Alzheimer's, Parkinson's and/or dementia, said composition comprising: (i) at least 50 mg nucleoside and/or nucleotide per 100 ml; (ii) between 0.2 and 10 grams protein per 100 ml; (iii) between 0.05 and 3 wt. % of thickener, based on total weight of the composition. The thickener is preferably selected from the group consisting of cellulose, xanthan gum, gellan gum, alginate, guar gum, locust bean gum, gum karaya, gum tragacanth, carrageenan, and mixtures thereof. The composition preferably has a loss factor tan δ between 0.1 and 100, as measured at any strain in the range of 1-100% at 0.1 Hz and 20° C. It is particularly found that a thickener selected from the group consisting of gellan gum, xanthan gum and cellulose greatly reduces sedimentation.

1 . A method for preventing and/or treating memory decline and/or cognitive dysfunction, Alzheimer's, Parkinson's and/or dementia, the method comprising administering to a person in need thereof a composition comprising:
 (i) at least 50 mg nucleoside and/or nucleotide per 100 ml of the composition;   (ii) between 0.2 and 10 grams protein per 100 ml of the composition; and   (iii) between 0.05 and 3 wt. % of thickener, based on total weight of the composition,
 wherein the thickener is selected from the group consisting of cellulose, xanthan gum and gellan gum, and mixtures thereof. 
   
     
     
         2 . The method according to  claim 1 , wherein the thickener comprises cellulose. 
     
     
         3 . The method according to  claim 1 , wherein the composition comprises a mixture of microcrystalline cellulose (MCC) and an anionic polymeric polysaccharide. 
     
     
         4 . The method according to  claim 3 , wherein the mixture comprises 0.05-1.0 wt % of the composition. 
     
     
         5 . The method according to  claim 3 , wherein the anionic polymeric polysaccharide is carboxymethyl cellulose (CMC). 
     
     
         6 . The method according to  claim 1 , wherein the composition has a loss factor tan δ between 0.1 and 100, as measured at any strain in the range of 1-100% at 0.1 Hz and 20° C. 
     
     
         7 . The method according to  claim 1 , the composition having shear-thinning and/or thixotropic properties. 
     
     
         8 . The method according to  claim 1 , the composition further comprising between 10 and 150 mg calcium per 100 kcal. 
     
     
         9 . The method according to  claim 1 , the composition comprising nucleotide, wherein the nucleotide provides at least 30 wt. % of total phosphorus in the composition. 
     
     
         10 . The method according to  claim 8 , wherein (a) nucleotide provides at least 30 wt. % of total phosphorus in the composition or (b) the composition comprises a weight ratio of protein to calcium of at least 5. 
     
     
         11 . The method according to  claim 8 , wherein the composition comprises a weight ratio of protein to calcium of at least 10. 
     
     
         12 . The method according to  claim 1 , wherein the composition has a dry matter content between 10 and 40%. 
     
     
         13 . The method according to  claim 1 , wherein the composition comprises at least one cellulose selected from the group consisting of high viscous cellulose and cellulose derivatives like hydroxyethyl cellulose, hydroxypropyl methyl cellulose, carboxymethyl cellulose, microcrystalline cellulose and methyl cellulose. 
     
     
         14 . The method according to  claim 1 , wherein the composition comprises uridine monophosphate (UMP) in an amount of 0.08-3 g per 100 ml of the composition. 
     
     
         15 . The method according to  claim 1 , wherein the composition comprises 50 mg to 3 gram choline per 100 ml of the composition. 
     
     
         16 . The method according to  claim 15 , wherein the choline is in the form of choline chloride. 
     
     
         17 . A liquid composition comprising:
 (i) at least 50 mg nucleoside and/or nucleotide per 100 ml of the composition;   (ii) between 0.2 and 10 grams protein per 100 ml of the composition; and   (iii) between 0.05 and 3 wt. % of thickener, based on total weight of the composition,   
       wherein the thickener is selected from the group consisting of cellulose, xanthan gum and gellan gum, and mixtures thereof. 
     
     
         18 . The liquid composition according to  claim 14 , wherein the composition has a loss factor tan δ between 0.1 and 100, as measured at any strain in the range of 1-100% at 0.1 Hz and 20° C. 
     
     
         19 . The liquid composition according to  claim 14 , comprising between 10 and 150 mg calcium per 100 kcal. 
     
     
         20 . The liquid composition according to  claim 14 , comprising nucleotide, wherein the nucleotide provides at least 30 wt. % of total phosphorus in the composition. 
     
     
         21 . A nutritional composition comprising a nucleotide and a thickener characterized in that the nucleotide provides more than 30 wt. % of the amount of phosphorous that is present in the total composition, and the composition comprises 30 to 80 mg phosphorus per 100 kcal. 
     
     
         22 . The nutritional composition according  claim 21 , further comprising protein and/or a mineral. 
     
     
         23 . The nutritional composition according to  claim 21 , which has been subjected to a ultra high temperature (UHT) treatment. 
     
     
         24 . The nutritional composition according to  claim 21 , further comprising intact protein.