Hydrophilic coating

Abstract

A hydrophilic, lubricious coating for a substrate includes a first coating layer having a cross-linked polyurethane or polyurea complexed with poly(ethylene oxide) formed by reacting a mixture of an isocyanate, a polyol or polyamine, and a poly(ethylene oxide), and a second coating layer having a cross-linked polyurethane or polyurea complexed with polyvinylpyrrolidone formed by reacting a mixture of an isocyanate, a polyol or polyamine, and a polyvinylpyrrolidone. The first layer is substantially covered by the second layer and the second layer at least partially interpenetrates the first layer. The coating is provided by applying the first coating layer, curing to provide a cross-linked polyurethane or polyurea/poly(ethylene oxide) coating, applying the second layer, and curing to provide a cross-linked polyurethane or polyurea/polyvinylpyrrolidone coating.

1 . A hydrophilic, lubricious coating for a substrate, comprising:
 a first hydrophilic, lubricious coating layer made from a poly(ethylene oxide) based coating material; and   a second hydrophilic, lubricious coating layer made from a polyvinylpyrrolidone based coating material;   wherein said second coating layer covers and interpenetrates said first coating layer.   
     
     
         2 . The coating of  claim 1  wherein said poly(ethylene oxide) based coating material is a cross-linked polyurethane and a poly(ethylene oxide). 
     
     
         3 . The coating of  claim 1  wherein said poly(ethylene oxide) based coating material is a cross-linked polyurea and a poly(ethylene oxide). 
     
     
         4 . The coating of  claim 1 , wherein said polyvinylpyrrolidone based coating material is a cross-linked polyurethane and a polyvinylpyrrolidone. 
     
     
         5 . The coating of  claim 1 , wherein said polyvinylpyrrolidone based coating material is a cross-linked polyurea and a polyvinylpyrrolidone. 
     
     
         6 . A method for providing a hydrophilic, lubricious coating on a surface of a substrate, comprising:
 applying a first coating layer of a poly(ethylene oxide) based coating material on said surface of said substrate;   curing said first coating layer;   applying a second coating layer of a polyvinylpyrrolidone based coating material over said first coating layer; and   curing said second coating layer where said second coating layer covers and interpenetrates said first coating layer.   
     
     
         7 . The method of  claim 6  including using a cross-linked polyurethane and a poly(ethylene oxide) as said first coating layer and using a cross-linked polyurethane and a polyvinylpyrrolidone as said second coating layer. 
     
     
         8 . The method of  claim 6 , including using a cross-linked polyurethane and a poly(ethylene oxide) as said first coating layer and using a cross-linked polyurea and a polyvinylpyrrolidone as said second coating layer. 
     
     
         9 . The method of  claim 6  including using a cross-linked polyurea and a poly(ethylene oxide) as said first coating layer and using a cross-linked polyurethane and a polyvinylpyrrolidone as said second coating layer. 
     
     
         10 . The method of  claim 6  including using a cross-linked polyurea and a poly(ethylene oxide) as said first coating layer and using a cross-linked polyurea and a polyvinylpyrrolidone as said second coating layer. 
     
     
         11 . The method of  claim 6  including applying said first coating layer by one of dipping, spraying, brushing, rolling or wiping. 
     
     
         12 . The method of  claim 6  including applying said second coating layer by one of dipping, spraying, brushing, rolling or wiping. 
     
     
         13 . A medical device, comprising:
 a substrate defining a balloon catheter shaft, a balloon or both;   a first hydrophilic, lubricious coating layer disposed on said substrate, said first coating layer being made from a poly(ethylene oxide) based coating material;   a second hydrophilic, lubricious coating layer covering said first coating layer, said second coating layer being made from a polyvinylpyrrolidone based coating material;   wherein said second coating layer interpenetrates said first coating layer.   
     
     
         14 . The device of  claim 13  wherein said poly(ethylene oxide) based coating material is a cross-linked polyurethane and a poly(ethylene oxide) and said polyvinylpyrrolidone based coating material is a cross-linked polyurethane and a polyvinylpyrrolidone. 
     
     
         15 . The device of  claim 13 , wherein said poly(ethylene oxide) based coating material is a cross-linked polyurethane and a poly(ethylene oxide) and said polyvinylpyrrolidone based coating material is a cross-linked polyurea and a polyvinylpyrrolidone. 
     
     
         16 . The device of  claim 13  wherein said poly(ethylene oxide) based coating material is a cross-linked polyurea and a poly(ethylene oxide) and said polyvinylpyrrolidone based coating material is a cross-linked polyurethane and a polyvinylpyrrolidone. 
     
     
         17 . The device of  claim 13 , wherein said poly(ethylene oxide) based coating material is a cross-linked polyurea and a poly(ethylene oxide) and said polyvinylpyrrolidone coating material is a cross-linked polyurea and a polyvinylpyrrolidone. 
     
     
         18 . The device of  claim 13 , wherein said poly(ethylene oxide) has an average molecular weight of from about 100,000 to about 600,000. 
     
     
         19 . The device of  claim 13 , wherein said polyvinylpyrrolidone has an average molecular weight of from about 50,000 to 2.5 million. 
     
     
         20 . The device of  claim 13 , wherein the medical device in any one of a catheter, a balloon catheter, a urinary catheter, a catheter introducer, a medical wire, a stent, a stent graft or a dilation balloon.