Non-fermented compositions comprising a cereal based fraction and a probiotic and uses thereof

Abstract

The present invention relates to a non-fermented composition having the ability to increase the formation of butyric acid in the colon and comprising at least one cereal based fraction and at least one isolated probiotic strain of Lactobacillus as well as the use of said non-fermented composition as a synbiotic and for treatment of the metabolic syndrome, ulcerative colitis, Crohns disease, Irritable bowel syndrome (IBS), or Inflammatory bowel disease (IBD). The non-fermented composition of the invention is useful for the maintenance of a healthy gut-mucosa and/or for the provision of an increased barrier function of the gutmucosa.

1 . A non-fermented composition having the ability to increase the formation of butyric acid in the colon comprising at least one cereal based fraction and at least one isolated probiotic strain of  Lactobacillus , wherein the at least one cereal based fraction is a barley fraction and is present in the non-fermented composition in the range of 40-100% weight. 
     
     
         2 . The non-fermented composition according to  claim 1 , wherein the at least one cereal based fraction is a whole grain cereal fraction. 
     
     
         3 . The non-fermented composition according to  claim 1 , wherein the at least one cereal based fraction is a milled and/or heat treated cereal based fraction, an extruded, expanded cereal based fraction, a drum-dried cereal based fraction, a flaked cereal based fraction or a steam-cooked cereal based fraction. 
     
     
         4 . The non-fermented composition according to  claim 1 , wherein the at least one cereal based fraction is additionally malted. 
     
     
         5 . The non-fermented composition according to  claim 1 , wherein the at least one isolated strain of  Lactobacillus  is present in an amount of 10 6 -10 14  CFU/day. 
     
     
         6 . A dry, non-fermented composition having the ability to increase the formation of butyric acid in the colon comprising at least one cereal based fraction and at least one isolated probiotic strain of  Lactobacillus , wherein the at least one cereal based fraction is a barley fraction and said barley fraction is present in the non-fermented composition as brewer's spent grain and the at least one isolated strain of  Lactobacillus  is present in an amount of 10 6 -10 14  CFU/day. 
     
     
         7 . The non-fermented composition according to  claim 1 , wherein the size of the at least one cereal based fraction is in the range of approximately 0.1 mm-10 mm. 
     
     
         8 . The non-fermented composition according to  claim 1 , wherein the at least one isolated probiotic strain of  Lactobacillus  is selected from the group consisting of  Lactobacillus plantarum, Lactobacillus paraplantarum, Lactobacillus pentosus, Lactobacillus rhamnosus, Lactobacillus paracasei  and  Lactobacillus fermentum.    
     
     
         9 . The non-fermented composition according to  claim 8 , wherein the at least one isolated probiotic strain is a  Lactobacillus rhamosus  271, DSM 6594. 
     
     
         10 . The non-fermented composition according to  claim 8 , wherein the at least one probiotic strain is selected from the group consisting of  Lactobacillus plantarum  299, DSM 6595,  Lactobacillus plantarum  299v, DSM 9843 , Lactobacillus plantarum  HEAL 9, DSM 15312,  Lactobacillus plantarum  HEAL 19, DSM 15313, and  Lactobacillus plantarum  HEAL 99, DSM 15316. 
     
     
         11 . The non-fermented composition according to  claim 1 , wherein said composition is a medical food, a functional food, a dietary supplement, a nutritional product, a food or a food additive. 
     
     
         12 . The non-fermented composition according to  claim 11 , wherein the non-fermented composition is a food additive present in cereals, muesli, breads, biscuits, cereals, health bars, or spreads. 
     
     
         13 . The non-fermented composition according to  claim 11 , wherein the non-fermented composition is a food, wherein the food is a drink, a beverage, a yogurt, a juice or an ice cream. 
     
     
         14 . A method for treating metabolic syndrome, ulcerative colitis, Crohns disease, Irritable bowel syndrome (IBS), or Inflammatory bowel disease (IBD) in a subject in need thereof, the method comprising administering to the subject a composition according to  claim 1 . 
     
     
         15 . A method of maintaining a healthy gut-mucosa and/or for providing an increased barrier function of the gut-mucosa, the method comprising consuming a composition according to  claim 1 . 
     
     
         16 . (canceled) 
     
     
         17 . (canceled) 
     
     
         18 . The non-fermented composition according to  claim 5 , wherein the at least one isolated strain of  Lactobacillus  is present in an amount of 10 8 -10 12  CFU/day. 
     
     
         19 . The non-fermented composition according to  claim 5 , wherein the at least one isolated strain of  Lactobacillus  is present in an amount of 10 9 -10 11  CFU/day. 
     
     
         20 . The dry, non-fermented composition according to  claim 6 , wherein the at least one isolated strain of  Lactobacillus  is present in an amount of 10 8 -10 12  CFU/day. 
     
     
         21 . The dry, non-fermented composition according to  claim 6 , wherein the at least one isolated strain of  Lactobacillus  is present in an amount of 10 9 -10 11  CFU/day. 
     
     
         22 . The non-fermented composition according to  claim 1 , wherein the non-fermented composition is a symbiotic composition. 
     
     
         23 . A method of increasing the formation of butyric acid in the colon of a subject, the method comprising consuming a composition according to  claim 1 . 
     
     
         24 . The non-fermented composition according to  claim 6 , wherein the at least one isolated probiotic strain of  Lactobacillus  is selected from the group of  Lactobacillus plantarum, Lactobacillus paraplantarum, Lactobacillus pentosus, Lactobacillus rhamnosus, Lactobacillus paracasei  and  Lactobacillus fermentum.    
     
     
         25 . The non-fermented composition according to  claim 24 , wherein the at least one isolated probiotic strain is a  Lactobacillus rhamnosus  271, DSM 6594. 
     
     
         26 . The non-fermented composition according to  claim 24 , wherein the at least one probiotic strain is selected from the group consisting of  Lactobacillus plantarum  299, DSM 6595,  Lactobacillus plantarum  299v, DSM 9843,  Lactobacillus plantarum  HEAL 9, DSM 15312,  Lactobacillus plantarum  HEAL 19, DSM 15313, and  Lactobacillus plantarum  HEAL 99, DSM 15316. 
     
     
         27 . A method for treating metabolic syndrome, ulcerative colitis. Crohns disease, Irritable bowel syndrome (IBS), or Inflammatory bowel disease (IBD) in a subject in need thereof, the method comprising administering to the subject a composition according to  claim 6 . 
     
     
         28 . A method of maintaining a healthy gut-mucosa and/or for providing an increased barrier function of the gut-mucosa, the method comprising consuming a composition according to  claim 6 .