US2012288537A1PendingUtilityA1

Active self-healing biomaterial system

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Individually held — no corporate assignee on recordPriority: Jan 13, 2010Filed: Jan 13, 2011Published: Nov 15, 2012
Est. expiryJan 13, 2030(~3.5 yrs left)· nominal 20-yr term from priority
Inventors:Steven P. SchwendemanKashappa-Goud Desai
A61P 35/00A61P 37/00A61K 47/593A61K 47/6923A61K 47/6937A61K 38/385A61K 9/1694A61K 38/47A61K 38/38A61K 47/6921A61K 39/08A61K 47/52A61K 38/09A61K 9/1647A61P 15/00
42
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Claims

Abstract

Methods and compositions are provided that load and encapsulate an agent, such as a protein, in a porous self-healing polymer. A delivery system includes a porous self-healing polymer, an ionic affinity trap within the pores of the self-healing polymer, and an agent associated with the ionic affinity trap. Methods of encapsulating an agent in a polymer include providing a porous self-healing polymer comprising an ionic affinity trap within the pores. The polymer is incubated with an agent having an affinity for the ionic affinity trap. At least a portion of the pores in the polymer are then healed. Active encapsulation of macromolecules at low concentrations may be achieved due to affinity of the agent for the ionic affinity trap within the pores.

Claims

exact text as granted — not AI-modified
1 . A delivery system comprising a solid polymer matrix comprising an ionic affinity trap, the ionic affinity trap operable to sorb an agent from an aqueous solution. 
     
     
         2 . The delivery system of  claim 1 , further comprising an agent sorbed to the ionic affinity trap. 
     
     
         3 . The delivery system of  claim 1 , wherein the solid polymer matrix comprises a self-healing polymer. 
     
     
         4 . The delivery system of  claim 3 , wherein the self-healing polymer comprises a pore that comprises the ionic affinity trap. 
     
     
         5 . The delivery system of  claim 4 , wherein the self-healing polymer comprises a plurality of pores comprising the ionic affinity trap. 
     
     
         6 . The delivery system of  claim 5 , wherein at least a portion of the pores are interconnected. 
     
     
         7 . The delivery system of  claim 4 , further comprising an agent sorbed to the ionic affinity trap and wherein the pore partially or fully encapsulates the agent and prevents the agent from exiting the pore. 
     
     
         8 . The delivery system of  claim 1 , wherein the solid polymer matrix comprises a biodegradable polymer. 
     
     
         9 . The delivery system of  claim 1 , wherein the solid polymer matrix comprises a copolymer of lactic acid and glycolic acid. 
     
     
         10 . The delivery system of  claim 1 , wherein the solid polymer matrix comprises a microparticle or microsphere. 
     
     
         11 . The delivery system of  claim 1 , wherein the ionic affinity trap comprises a metal salt. 
     
     
         12 . The delivery system of  claim 1 , wherein the ionic affinity trap comprises aluminum hydroxide, aluminum phosphate, potassium phosphate, magnesium carbonate, calcium phosphate, or combinations thereof. 
     
     
         13 . The delivery system of  claim 1 , wherein the ionic affinity trap comprises an ionomer gel. 
     
     
         14 . The delivery system of  claim 1 , wherein the ionic affinity trap comprises ionized end groups of the polymer. 
     
     
         15 . The delivery system of  claim 14 , wherein the ionized end groups comprise carboxylate groups. 
     
     
         16 . The delivery system of  claim 2 , wherein the agent comprises a biomolecule, drug, or antigen. 
     
     
         17 . The delivery system of  claim 16 , wherein the biomolecule comprises a protein, peptide, proteoglycan, lipoprotein, or nucleic acid. 
     
     
         18 . The delivery system of  claim 2 , wherein the agent comprises an immunocontraceptive. 
     
     
         19 . The delivery system of  claim 1 , wherein the solid polymer matrix further comprises a plasticizer. 
     
     
         20 . A method of making a delivery system comprising sorbing an agent to an ionic affinity trap, wherein a solid polymer matrix comprises the ionic affinity trap and an aqueous solution comprises the agent. 
     
     
         21 . The method of  claim 20 , wherein the solid polymer matrix comprises a self-healing polymer. 
     
     
         22 . The method of  claim 21 , wherein the self-healing polymer comprises a pore that comprises the ionic affinity trap. 
     
     
         23 . The method of  claim 22 , wherein the self-healing polymer comprises a plurality of pores comprising the ionic affinity trap. 
     
     
         24 . The method of  claim 23 , wherein at least a portion of the pores are interconnected. 
     
     
         25 . The method of  claim 22 , further comprising partially or fully encapsulating the agent in the pore by increasing the temperature of the self-healing polymer to about its T g  or above. 
     
     
         26 . The method of  claim 20 , wherein the solid polymer matrix comprises a biodegradable polymer. 
     
     
         27 . The method of  claim 20 , wherein the solid polymer matrix comprises a copolymer of lactic acid and glycolic acid. 
     
     
         28 . The method of  claim 20 , wherein the solid polymer matrix comprises a microparticle or microsphere. 
     
     
         29 . The method of  claim 20 , wherein the ionic affinity trap comprises a metal salt. 
     
     
         30 . The method of  claim 20 , wherein the ionic affinity trap comprises aluminum hydroxide, aluminum phosphate, potassium phosphate, magnesium carbonate, calcium phosphate, or combinations thereof. 
     
     
         31 . The method of  claim 20 , wherein the ionic affinity trap comprises an ionomer gel. 
     
     
         32 . The method of  claim 20 , wherein the ionic affinity trap comprises ionized end groups of the self-healing polymer. 
     
     
         33 . The method of  claim 32 , wherein the ionized end groups comprise carboxylate groups. 
     
     
         34 . The method of  claim 20 , wherein the agent comprises a biomolecule, drug, or antigen. 
     
     
         35 . The method of  claim 34 , wherein the biomolecule comprises a protein, peptide, proteoglycan, lipoprotein, or nucleic acid. 
     
     
         36 . The method of  claim 20 , wherein the agent comprises an immunocontraceptive. 
     
     
         37 . The method of  claim 20 , wherein the solid polymer matrix further comprises a plasticizer. 
     
     
         38 . The method of  claim 20 , wherein the aqueous solution comprises less than about 1 mg/mL of the agent. 
     
     
         39 . The method of  claim 20 , wherein at least 90% of the agent in the sorbing step is sorbed to the ionic affinity trap.

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