Plastic container comprising cyclic polyolefin layer

Abstract

The present invention provides and a plastic container and multilayered films, which comprises a heat-sealable seal layer, a cyclic polyolefin layer, and an outermost layer, wherein the seal layer comprises polypropylene, the cyclic polyolefin layer comprises a cyclic polyolefin polymer or a cyclic polyolefin copolymer, and the outermost layer comprises a layer containing polypropylene, and which further comprises a resin composition layer comprises a blended product of a propylene polymer and a styrene elastomer. The plastic container of the present invention can suppresses a reduction in the medicament content of a liquid-state medicament and is excellent in terms of shock resistance, handling ability during the filling of the container with the medicament, and the moldability and transparency of the container.

1 - 18 . (canceled) 
     
     
         19 . A multilayered film, comprising a heat-sealable seal layer, a cyclic polyolefin layer, and an outermost layer, wherein the seal layer comprises polypropylene, the cyclic polyolefin layer comprises a cyclic polyolefin polymer or a cyclic polyolefin copolymer, and the outermost layer comprises a layer containing polypropylene, and said multilayered film further comprises a resin composition layer comprising a blended product of a propylene polymer and a styrene elastomer; provided that a five-layered plastic film composed of only a seal layer-an adhesive layer-a barrier layer-an adhesive layer-a material layer, wherein each of the seal layer and the material layer consists of only a polypropylene elastomer having a melting point of 165° C., each of the adhesive layers consists of only MODIC manufactured by Mitsubishi Chemical Corporation, and the barrier layer consists of only a cyclic polyolefin polymer having a glass transition temperature of 136° C., is excluded. 
     
     
         20 . A plastic container comprising:
 multilayered films each comprising a heat-sealable seal layer, a cyclic polyolefin layer, and an outermost layer, wherein the seal layer comprises polypropylene, the cyclic polyolefin layer comprises a cyclic polyolefin polymer or a cyclic polyolefin copolymer, and the outermost layer comprises a layer containing polypropylene; and   a resin composition layer comprising a blended product of a propylene polymer and a styrene elastomer, in a state in which the seal layers are laminated on each other such that they face each other;   wherein the plastic container is molded by heat sealing peripheral portions of the multilayered films; and   wherein the plastic container is filled with a solution comprising an active ingredient excluding a pyrazolone derivative represented by the formula (I), a physiologically acceptable salt thereof, a hydrate thereof, or a solvate thereof:   
       
         
           
           
               
               
           
         
         wherein R 1  represents a hydrogen atom, an aryl, an alkyl containing 1 to 5 carbon atoms, or an alkoxycarbonylalkyl containing 3 to 6 carbon atoms in total; R 2  represents a hydrogen atom, an aryloxy, an arylmercapto, an alkyl containing 1 to 5 carbon atoms, or a hydroxyalkyl containing 1 to 3 carbon atoms; or R 1  and R 2  together represent an alkylene containing 3 to 5 carbon atoms; R 3  represents a hydrogen atom, an alkyl containing 1 to 5 carbon atoms, a cycloalkyl containing 5 to 7 carbon atoms, a hydroxyalkyl containing 1 to 3 carbon atoms, a benzyl, naphthyl or phenyl, or a phenyl substituted with 1 to 3 identical or different substituents selected from the group consisting of an alkoxy containing 1 to 5 carbon atoms, a hydroxyalkyl containing 1 to 3 carbon atoms, an alkoxycarbonyl containing 2 to 5 carbon atoms in total, an alkylmercapto containing 1 to 3 carbon atoms, an alkylamino containing 1 to 4 carbon atoms, a dialkylamino containing 2 to 8 carbon atoms in total, a halogen atom, a trifluoromethyl, a carboxyl, a cyano, a hydroxyl group, a nitro, an amino, and an acetamide. 
       
     
     
         21 . The plastic container according to  claim 20 , further comprising a resin composition layer or a polyethylene layer on the surfaces of both sides of the cyclic polyolefin layer. 
     
     
         22 . The plastic container according to  claim 21 , which comprises a resin composition layer having a fusion peak temperature only in a temperature range from 120° C. or higher to 170° C. or lower and also having a heat of fusion from 5 J/g or more to 20 J/g or less on the surfaces of both sides of the cyclic polyolefin layer. 
     
     
         23 . The plastic container according to  claim 20 , wherein the cyclic polyolefin of the cyclic polyolefin layer is a ring-opening polymer hydrogenation product of dicyclopentadiene or a derivative thereof. 
     
     
         24 . The plastic container according to  claim 20 , wherein the cyclic polyolefin layer has a glass transition temperature (Tg) of 80° C. to 120° C. 
     
     
         25 . The plastic container according to  claim 20 , wherein the melt flow rate (230° C., 21.2 N) value of the cyclic polyolefin layer is 1 to 20 (g/10 minutes). 
     
     
         26 . The plastic container according to  claim 20 , wherein the melt flow rate (230° C., 21.2 N) value of the seal layer and/or the outermost layer is 1 to 4 (g/10 minutes). 
     
     
         27 . The plastic container according to  claim 20 , wherein the bending elasticity of the seal layer and/or the outermost layer is 400 to 600 MPa. 
     
     
         28 . The plastic container according to  claim 20 , wherein the maximum fusion peak temperature of the seal layer is 125° C. to 135° C. 
     
     
         29 . The plastic container according to  claim 20 , wherein the highest fusion peak temperature of the seal layer is 150° C. to 160° C. 
     
     
         30 . The plastic container according to  claim 20 , wherein the fusion peak temperature of the outermost layer is 160° C. to 170° C. 
     
     
         31 . The plastic container according to  claim 20 , wherein the plastic film has a tensile elasticity of 300 MPa or less. 
     
     
         32 . The plastic container according to  claim 20 , which can be sterilized at 115° C. for 30 minutes or more. 
     
     
         33 . The plastic container according to  claim 20 , which can be sterilized at 121° C. for 15 minutes or more. 
     
     
         34 . The plastic container according to  claim 20 , which is in the form of an infusion bag. 
     
     
         35 . The plastic container according to  claim 20 , which is placed together with an oxygen absorber into a poorly air-permeable container. 
     
     
         36 . A plastic container comprising:
 a heat-sealable seal layer, a cyclic polyolefin layer, and an outermost layer, wherein the seal layer comprises polypropylene, the cyclic polyolefin layer comprises a cyclic polyolefin polymer or a cyclic polyolefin copolymer, and the outermost layer comprises a layer containing polypropylene; and   a resin composition layer comprising a blended product of a propylene polymer and a styrene elastomer; but   
       excluding a five-layered plastic film composed only of a seal layer, an adhesive layer, a barrier layer, an adhesive layer and a material layer, wherein each of the seal layer and the material layer consists only of a polypropylene elastomer having a melting point of 165° C., each of the adhesive layers consists only of MODIC manufactured by Mitsubishi Chemical Corporation, and the barrier layer consists only of a cyclic polyolefin polymer having a glass transition temperature of 136° C.