US2012270939A1PendingUtilityA1

Formulations and methods for treating amyloidosis

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Assignee: GARCEAU DENISPriority: Apr 15, 2005Filed: May 15, 2012Published: Oct 25, 2012
Est. expiryApr 15, 2025(expired)· nominal 20-yr term from priority
Inventors:Denis GarceauWendy HauckRichard Briand
A61P 43/00A61P 29/00A61P 35/00A61P 31/00A61P 25/28A61P 25/00A61P 13/12A61K 31/16A61K 31/525A61K 31/185A61K 31/255A61K 45/06
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Claims

Abstract

Methods, formulations, and compositions for the treatment of amyloidosis are described.

Claims

exact text as granted — not AI-modified
1 . A method of treating or preventing AA amyloidosis in a target subject comprising,
 administering to the target subject a therapeutically effective amount of a compound having the formula:
   Y—(CH 2 ) n —[CH 2 Y] m   (I)
 
   
       wherein Y is SO 3 X or OSO 3 X independently chosen for each occurrence; X is cationic group independently chosen for each occurrence; n is 1, 2, 3 or 4; and m is 1 or 2, such that AA amyloidosis is treated or prevented while maintaining an acceptable tolerance index (ATI) for a parameter associated with renal impairment (PRI),
 wherein the target subject is being treated for AA amyloidosis and has or is susceptible to a parameter associated with renal impairment.

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