US2012264652A1PendingUtilityA1

Directed heterobifunctional linkers

28
Individually held — no corporate assignee on recordPriority: Aug 23, 2006Filed: Jun 21, 2012Published: Oct 18, 2012
Est. expiryAug 23, 2026(~0.1 yrs left)· nominal 20-yr term from priority
Inventors:Richard Moerschell
C40B 80/00C40B 50/18B01J 2219/00725B01J 2219/00659B01J 2219/00596
28
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Claims

Abstract

A heterobifunctional linker that comprises (a) a moiety capable of reversibly coupling the linker to a selected epitope of a target molecule; and (b) a moiety or moieties capable of irreversibly coupling the linker to the target, and optionally a moiety or moieties capable of irreversibly coupling the linker to a solid surface. Also described is a method of orienting molecules, such as proteins, with respect to a surface and to each other, employing such a linker, and an array of such oriented molecules, which may be the same or different.

Claims

exact text as granted — not AI-modified
1 . A method for producing a plurality of molecules coupling to a solid surface wherein the molecules are oriented with respect to each other, comprising
 (i) contacting the plurality of molecules with a linker comprising (a) a moiety capable of reversibly coupling to a selected epitope of the plurality of molecules; (b) a moiety or moieties capable of irreversibly coupling to the plurality of molecules, and (c) a moiety or moieties capable of irreversibly coupling to a solid surface, and   (ii) contacting the product of step (i) with the surface.   
     
     
         2 . A method according to  claim 1  in which the oriented molecules are identical molecules. 
     
     
         3 . A method according to  claim 1  in which the oriented molecules are different from each other. 
     
     
         4 . A method according to  claim 1  in which the oriented molecules are proteins. 
     
     
         5 . A method according to  claim 4  in which the proteins are different from each other. 
     
     
         6 . An array of oriented molecules coupled to a solid surface in which the coupling is performed using a linker that comprises (a) a moiety capable of reversibly coupling to selected epitope of a target molecule of interest, (b) a moiety or moieties capable of irreversibly coupling to the target molecule and (c) a moiety or moieties capable of irreversibly coupling to a solid surface. 
     
     
         7 . An array of oriented proteins according to  claim 6 . 
     
     
         8 . An array of oriented proteins according to  claim 6  that are different from each other.

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