US2012258534A1PendingUtilityA1
Method of delivering rna interference and uses thereof
Est. expiryAug 16, 2024(expired)· nominal 20-yr term from priority
C07K 2319/74C12N 15/1135C12N 15/1132C12N 2310/14C12N 2310/3513C07K 2319/85C12N 15/113C07K 2317/77C12N 2320/32A61P 35/00C12N 15/1136C12N 15/111A61P 31/12C12N 15/1138C07K 16/1145C07K 14/46
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Claims
Abstract
The invention provides a method of RNA interference, which comprises contacting the cell with a fusion protein-double stranded RNA complex, the complex comprising the double stranded RNA segment containing a double stranded RNA of interest and a fusion protein, the fusion protein comprising (1) a targeting moiety, which will specifically binds to a site on a target cell, and (2) a binding moiety, which will bind to the double stranded RNA, wherein the double stranded RNA segment initiates RNA interference in the cell.
Claims
exact text as granted — not AI-modified1 . A method of RNA interference in a cell, the method comprising contacting the cell with a fusion protein-double stranded RNA complex, the complex comprising: a) an RNA molecule comprising a double stranded RNA segment, wherein one of the strands is complementary and the other strand identical to an RNA interference target RNA; and b) a fusion protein, comprising (1) a targeting moiety, which specifically binds to a site on a target cell, and (2) a binding moiety, which binds to the double stranded RNA segment, wherein the double stranded RNA segment initiates RNA interference in the cell.
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