Transdermal granisetron

Abstract

Adhesive patches for the transdermal administration of granisetron, comprise an acrylic adhesive containing non-acidic nucleophilic moieties which substantially increase flux of granisetron across the skin.

1 . A method for the treatment and/or prophylaxis of nausea or emesis associated with 5-HT 3  receptor activity in a patient in need thereof, said method comprising applying an adhesive patch to the skin of the patient, wherein the adhesive patch comprises an acrylic adhesive containing non-acidic hydroxyl moieties, and a physiologically effective amount of granisetron loaded in the acrylic adhesive. 
     
     
         2 . The method of  claim 1 , wherein said emesis is acute. 
     
     
         3 . The method of  claim 1 , wherein said emesis is delayed. 
     
     
         4 . The method of  claim 1 , wherein said treatment and/or prophylaxis of emesis is associated with fractionated chemotherapy. 
     
     
         5 . The method of  claim 1 , wherein said treatment and/or prophylaxis of nausea or emesis is associated with radiotherapy. 
     
     
         6 . The method of  claim 1 , wherein said treatment and/or prophylaxis is for postoperative nausea and vomiting. 
     
     
         7 . The method of  claim 1 , wherein said granisetron is delivered in an amount effective for the treatment and/or prophylaxis of nausea or emesis within several hours. 
     
     
         8 . The method of  claim 1 , wherein said acrylic adhesive is loaded with between 3 and 12% w/w granisetron. 
     
     
         9 . The method of  claim 1 , wherein said acrylic adhesive is loaded with between 4 and 10% w/w granisetron. 
     
     
         10 . The method of  claim 1 , wherein said acrylic adhesive is loaded with between 5 and 8% w/w granisetron. 
     
     
         11 . The method of  claim 10 , wherein said acrylic adhesive is loaded with 6% and 7.7% w/w of granisetron. 
     
     
         12 . A method for the treatment and/or prophylaxis of chemotherapy induced nausea and vomiting in a patient in need thereof, said method comprising applying an adhesive patch to the skin of the patient, wherein the adhesive patch comprises an acrylic adhesive containing non-acidic hydroxyl moieties, and a physiologically effective amount of granisetron loaded in the acrylic adhesive. 
     
     
         13 . The method of  claim 12 , wherein said emesis is acute. 
     
     
         14 . The method of  claim 12 , wherein said emesis is delayed. 
     
     
         15 . The method of  claim 12 , wherein said treatment and/or prophylaxis of emesis is associated with fractionated chemotherapy. 
     
     
         16 . The method of  claim 12 , wherein said granisetron is delivered in an amount effective for the treatment and/or prophylaxis of nausea or emesis within several hours. 
     
     
         17 . The method of  claim 12 , wherein said acrylic adhesive is loaded with between 3 and 12% w/w granisetron. 
     
     
         18 . The method of  claim 12 , wherein said acrylic adhesive is loaded with between 5 and 8% w/w granisetron. 
     
     
         19 . The method of  claim 18 , wherein said acrylic adhesive is loaded with 6% and 7.7% w/w of granisetron. 
     
     
         20 . A method for the treatment and/or prophylaxis of a patient having, or susceptible to, a condition selected from the group consisting of:
 pruritus, fibromyalgia and pain associated therewith, migraine, anxiety, cognitive and psychotic disorders, depression, schizophrenia, psychosis in postnatal depression, irritable bowel syndrome, alcoholism, obstructive sleep disturbed breathing, motion sickness, loss of cognitive function, urinary incontinence, dyskinesia, systemic lupus erythematosus, drug-induced pruritus, premature ejaculation, eating disorders, obsessive compulsive disorder, gastric motility disorders, chronic fatigue syndrome, dyspepsia and cocaine dependence,   said method comprising applying an adhesive patch to the skin of the patient, wherein said adhesive patch comprises an acrylic adhesive containing non-acidic hydroxyl moieties, and a physiologically effective amount of granisetron loaded in the acrylic adhesive.