Metal-binding therapeutic peptides

Abstract

The present invention is related methods of delivering MBD peptide-linked agents into live cells. The methods described herein comprise contacting MBD peptide-linked agents to live cells under a condition of cellular stress. The methods of the invention may be used for therapeutic or diagnostic purposes.

1 - 36 . (canceled) 
     
     
         37 . A polypeptide comprising the sequence SDKPDMAPRGFSCLLLLTGEIDLPV (SEQ ID NO:245). 
     
     
         38 . A composition comprising the polypeptide of  claim 37  and a pharmaceutical excipient. 
     
     
         39 . A nucleic acid encoding the polypeptide of  claim 37 . 
     
     
         40 . A vector comprising the nucleic acid of  claim 39 . 
     
     
         41 . A method of treating an inflammatory disease condition comprising administering an effective amount of a polypeptide to a mammal, wherein said polypeptide comprises and amino acid sequence selected from the group consisting of SDKPDMAPRGFSCLLLLTGEIDLPV (SEQ ID NO:245), humanin (SEQ ID NO:188), and humanin-S14G (SEQ ID NO:189); and said inflammatory disease condition is selected from the group consisting of cancer, cardiomyopathy, nephropathy, retinopathy, obesity, lupus, autoimmune disease, rheumatological disease and infectious disease. 
     
     
         42 . The method of  claim 41 , wherein the nephropathy is diabetic nephropathy. 
     
     
         43 . The method of  claim 41  wherein the polypeptide is administered via a route selected from the group consisting of intravenous, oral, subcutaneous, intraarterial, intramuscular, intracardial, intraspinal, intrathoracic, intraperitoneal, intraventricular, sublingual, transdermal, and inhalation. 
     
     
         44 . A method of treating an inflammatory disease condition comprising administering the nucleic acid of  claim 39  to a mammal; said inflammatory disease condition is selected from the group consisting of cancer, diabetes, cardiovascular disease, kidney disease, retinopathy, obesity, metabolic disease, neurodegenerative disease, gastrointestinal disease, lupus, autoimmune disease, rheumatological disease and infectious disease.