Compositions and methods for controlling diseases in animals

Abstract

Disclosed herein are compositions for the treatment of a disease in an animal including yeast extract of Saccharomyces cerevisiae, Bacillus licheniformis or Bacillus subtilis spores, and a carrier. Also included are animal feed compositions including the composition for the prevention, control and/or treatment of a disease in an animal and an animal's food/feed. The compositions are useful to prevent, control, and treat diseases such as necrotic enteritis in poultry when used in combination with an anticoccidal ionophore or coccidiosis vaccine.

1 . A composition for the treatment of a disease in an animal comprising: yeast extract from  Saccharomyces cerevisiae, Bacillus licheniformis  spores, and optionally a carrier. 
     
     
         2 . The composition of  claim 1 , comprising
 (a) about 50 wt. % to about 90 wt. % of the cell wall fraction from  Saccharomyces cerevisiae,      (b) about 5 wt. % to about 50 wt. % of the  Bacillus licheniformis  spores, comprising about 4.5×10 9  to about 2.5×10 10  spores per gram, and   (c) about 0 wt. % to about 45 wt. % of the carrier.   
     
     
         3 . The composition of  claim 1 , comprising
 (a) 50 wt. % of the cell wall fraction from  Saccharomyces cerevisiae,      (b) 10 wt. % of the  Bacillus licheniformis  spores, comprising about 5×10 9  to about 1.25×10 10  spores per gram, and   (c) 40 wt. % of the carrier.   
     
     
         4 . The composition of  claim 1  wherein the carrier comprises calcium carbonate, calcium sulfate, lactose, or a combination thereof. 
     
     
         5 . An animal feed composition comprising the composition for the treatment of a disease in an animal of any one of  claims 1 - 4 , and an animal foodstuff; wherein the composition for the treatment of a disease in an animal is in an amount of about 0.5 pounds to about 10 pounds per ton of the animal foodstuff. 
     
     
         6 . The animal feed composition of  claim 5 , wherein the composition for the treatment of a disease in an animal is in an amount of about 1 pound to about 5 pounds per ton of the animal foodstuff. 
     
     
         7 . The animal feed composition of  claim 6 , wherein the composition for the treatment of a disease in an animal is in an amount of about 2 pounds per ton of the animal foodstuff. 
     
     
         8 . The animal food composition of  claim 7 , wherein animal foodstuff is a poultry foodstuff or a swine foodstuff. 
     
     
         9 . A method for preventing a disease in an animal, comprising administering to the animal the composition for the treatment of a disease in an animal of any one of  claims 1 - 8 . 
     
     
         10 . The method of  claim 9 , wherein the animal is poultry and the disease is necrotic enteritis. 
     
     
         11 . The method of  claim 9 , wherein the animal is swine and the disease is swine ileitis. 
     
     
         12 . A composition for the prevention and/or control of a disease in an animal comprising a yeast extract from  Saccharomyces cerevisiae  and QST-713 strain of  Bacillus subtilis,  and optionally a carrier. 
     
     
         13 . The composition according to  claim 12 , comprising from about 75 wt-% to about 99 wt-% of the yeast extract from  Saccharomyces cerevisiae;  from about 1 wt-% to about 3 wt-% of the QST-713 strain of  Bacillus subtilis;  and from about 0 wt-% to about 24 wt-% of the carrier. 
     
     
         14 . The composition according to  claim 12 , comprising 80 wt-% of the cell wall fraction from  Saccharomyces cerevisiae;  2.5 wt-% of QST-713 strain of  Bacillus subtilis;  and 17.5 wt-% of the carrier. 
     
     
         15 . The composition according to  claim 12 , wherein the carrier comprises calcium carbonate, calcium sulfate, lactose, or a combination thereof. 
     
     
         16 . An animal feed composition comprising a composition according to any one of  claims 12  to  15 , and an animal foodstuff, wherein the composition for the prevention and/or control of a disease in an animal is present in an amount ranging from about 0.5 pounds to about 10 pounds per ton of the animal foodstuff. 
     
     
         17 . The animal feed composition according to  claim 16 , wherein the composition for the prevention and/or control of a disease in an animal is in an amount of about 1.25 pounds per ton of the animal foodstuff. 
     
     
         18 . The animal feed composition according to  claim 16 , wherein animal foodstuff is a poultry foodstuff or a swine foodstuff. 
     
     
         19 . A method for preventing and/or controlling a disease in an animal comprising administering to the animal an effective amount of a composition according to any one of  claims 12  to  18 . 
     
     
         20 . The method according to  claim 19 , wherein the animal is poultry and the disease is necrotic enteritis. 
     
     
         21 . The method according to  claim 19 , wherein the animal is swine and the disease is swine ileitis. 
     
     
         22 . A composition comprising the composition of any one of  claims 1  to  8  further comprising an anticoccidal ionophore. 
     
     
         23 . The composition of  claim 22 , wherein the anticoccidal ionophore is salinomycin. 
     
     
         24 . The composition of  claim 23 , wherein the salinomycin is present at a level of about 66 ppm of the composition. 
     
     
         25 . An animal feed composition comprising the composition for the treatment of necrotic enteritis in an animal of any one of  claims 22  to  24 , and an animal foodstuff, wherein the composition for the treatment of a disease in an animal is in an amount of about 0.5 pounds to about 10 pounds per ton of the animal foodstuff. 
     
     
         26 . A method for improving the performance of an ionophore in the treatment of necrotic enteritis in an animal comprising administering to the animal the composition of any one of  claims 22  to  25 . 
     
     
         27 . The method of  claim 26  wherein the ionophore is salinomycin. 
     
     
         28 . A method for preventing disease in an animal, comprising
 vaccinating the animal with a coccidiosis vaccine; and   administering to the animal a composition comprising the composition of any one of  claims 1  to  8 .   
     
     
         29 . The method of  claim 28 , wherein the animal is poultry and the disease is necrotic enteritis. 
     
     
         30 . The method of  claim 28 , wherein the vaccine comprises a non-attenuated, live sporulated oocyst coccidiosis vaccine. 
     
     
         31 . The method of  claim 28 , wherein the coccidiosis vaccine is Coccivac®. 
     
     
         32 . A method for decreasing the mortality in an animal challenged with  C. perfringens,  comprising vaccinating the animal with a coccidiosis vaccine; and
 administering to the animal a composition comprising the composition of any one of  claims 1  to  8 .   
     
     
         33 . The method of  claim 32  wherein the animal is poultry. 
     
     
         34 . The method of  claim 33 , wherein the vaccine comprises a non-attenuated, live sporulated oocyst coccidiosis vaccine. 
     
     
         35 . The method of  claim 34 , wherein the coccidiosis vaccine is Coccivac®. 
     
     
         36 . A method for decreasing the necrotic enteritis lesions in an animal challenged with  C. perfringens,  comprising vaccinating the animal with a coccidiosis vaccine; and administering to the animal a composition comprising the composition of any one of  claims 1  to  8 . 
     
     
         37 . The method of  claim 36  wherein the animal is poultry. 
     
     
         38 . The method of  claim 36 , wherein the vaccine comprises a non-attenuated, live sporulated oocyst coccidiosis vaccine. 
     
     
         39 . A composition comprising the composition of any one of  claims 12  to  18  further comprising an anticoccidal ionophore. 
     
     
         40 . The composition of  claim 39 , wherein the anticoccidal ionophore is salinomycin: 
     
     
         41 . The composition of  claim 40 , wherein the salinomycin is present at a level of about 66 ppm of the composition. 
     
     
         42 . An animal feed composition comprising the composition for the treatment of necrotic enteritis in an animal of any one of  claims 39  to  41 , and an animal foodstuff, wherein the composition for the treatment of a disease in an animal is in an amount of about 0.5 pound to about 10 pounds per ton of the animal foodstuff. 
     
     
         43 . A method for improving the performance of an ionophore in the treatment of necrotic enteritis in an animal comprising administering to the animal the composition of any one of  claims 39  to  41 . 
     
     
         44 . The method of  claim 43  wherein the ionophore is salinomycin. 
     
     
         45 . A method for preventing disease in an animal, comprising
 vaccinating the animal with a coccidiosis vaccine; and   administering to the animal a composition comprising the composition of any one of  claims 12  to  18 .   
     
     
         46 . The method of  claim 45 , wherein the animal is poultry and the disease is necrotic enteritis. 
     
     
         47 . The method of  claim 45 , wherein the vaccine comprises a non-attenuated, live sporulated oocyst coccidiosis vaccine. 
     
     
         48 . The method of  claim 45 , wherein the coccidiosis vaccine is Coccivac®.