Protein markers for detecting liver cancer and method for identifying the markers thereof

Abstract

The present invention relates to the diagnosis of liver cancer. It discloses the use of protein ERBB3 and protein IGFBP2 in the diagnosis of liver cancer. It relates to a method for diagnosis of liver cancer from a liquid sample, derived from an individual by measuring ERBB3 protein and IGFBP2 protein in the sample. Measurement of ERBB3 protein and IGFBP2 protein can, e.g., be used in the early detection or diagnosis of liver cancer.

1 . A method for detection of liver cancer, comprising steps of:
 a) providing a liquid sample obtained from an individual,   b) contacting said sample with an antibody specific for at least one of ERBB3 protein (SEQ ID NO:2) under conditions appropriate for formation of a complex between said antibody and at least one of said proteins, and   c) correlating an amount of the complex formed in step d) to the detection of liver cancer.   
     
     
         2  and  3 . (canceled) 
     
     
         4 . The method according to  claim 1  wherein the liquid sample is whole blood. 
     
     
         5 - 9 . (canceled)