Methods and pharmaceutical compositions useful for treating psoriasis

Abstract

Pharmaceutical or cosmetic compositions including cruciferous plant extract or isothiocyanates such as 4-methyl-thio-butyl-isothiocyanate which are useful for treating psoriasis are provided.

1 . A topical composition comprising a synthetic isothiocyanate and a pharmaceutical acceptable carrier formulated for topical application. 
     
     
         2 . The topical composition of  claim 1 , wherein said synthetic isothiocyanate is selected from the group consisting of 2-Propenyl-isothiocyanate, 3-Butenyl-isothiocyanate, 2R-2-Hydroxy-3-butenyl-isothiocyanate, 2S-2-Hydroxy-3-butenyl-isothiocyanate, p-Hydroxy-benzyl-isothiocyanate, Benzyl-isothiocyanate, 4-Methyl-thio-butyl-isothiocyanate, 3-Methyl-sulfonyl-propyl-isothiocyanate and 4-Methyl-sulfinyl-butenyl-isothiocyanate. 
     
     
         3 . The topical composition of  claim 1 , wherein said pharmaceutical acceptable carrier is a dermatological acceptable carrier. 
     
     
         4 . The topical composition of  claim 1 , wherein said pharmaceutical acceptable carrier is selected from the group consisting of an emulsion, a cream, an ointment, an aqueous solution, a lotion and an aerosol. 
     
     
         5 . The topical composition of  claim 4 , wherein said emulsion comprises oil-in-water, water-in-oil, water-in-oil-in-water, or oil-in-water-in-silicone emulsions.