Method for producing a radioactively marked carboxylate

Abstract

A method produces a radioactively marked carboxylate, at least one precursor molecule of the carboxylate being prepared in a solvent including a conductive salt. Radioactively marked carbon dioxide is fed into the solvent. The precursor molecule is electrochemically reacted with the radioactively marked carbon dioxide to form the radioactively marked carboxylate. The radioactively marked carbon dioxide is completely dissolved in the solvent when the precursor molecule is reacted. The radioactively marked carbon dioxide is used for electrochemically synthesizing a radioactively marked carboxylate, the carbon dioxide being completely dissolved in a solvent during synthesis. A microstructure is used for electrochemically synthesizing the radioactively marked carboxylate, radioactively marked carbon dioxide being reacted.

1 - 19 . (canceled) 
     
     
         20 . A method for producing a radioactively labeled carboxylate, comprising:
 providing a precursor molecule of the carboxylate in a solvent which comprises a conductive salt;   introducing a reactant which comprises radioactively labeled carbon dioxide into the solvent;   electrochemically producing a reaction of the precursor molecule with the radioactively labeled carbon dioxide to produce the radioactively labeled carboxylate; and   completely dissolving the radioactively labeled carbon dioxide in the solvent before the reaction of the precursor molecule.   
     
     
         21 . The method as claimed in  claim 20 , wherein
 the carboxylate is an alpha-hydroxy acid salt and/or an alpha-amino acid salt.   
     
     
         22 . The method as claimed in  claim 20 , wherein
 the precursor molecule is selected from the group consisting of a ketimine, an aldimine, a ketone, an aldehyde and ions thereof.   
     
     
         23 . The method as claimed in  claim 20 , wherein
 the conductive salt is selected from the group consisting of an alkali metal halide, an alkaline earth metal halide, an ammonium halide, an alkyl-, cycloalkyl-, or aryl-ammonium salt, and a quaternary ammonium salt.   
     
     
         24 . The method as claimed in  claim 20 , wherein
 the conductive salt is selected from the group consisting of tetra(C 1 -C 4 )alkylammonium tetrafluoroborate and tetra(C 1 -C 4 )alkylammonium hexafluorophosphate.   
     
     
         25 . The method as claimed in  claim 20 , wherein
 the solvent is an organic solvent selected from the group consisting of an amide, a nitrile, N,N-dimethylformamide, an open-chain ether, and a cyclic ether.   
     
     
         26 . The method as claimed in  claim 20 , wherein
 the reactant is reacted with the precursor molecule in only one step to produce the carboxylate.   
     
     
         27 . The method as claimed in  claim 20 , wherein
 the radioactively labeled carbon dioxide is  11 CO 2 .   
     
     
         28 . The method as claimed in  claim 20 , wherein
 the carbon dioxide is introduced into the solvent under a pressure of more than 2 bar.   
     
     
         29 . The method as claimed in  claim 20 , wherein
 the carbon dioxide is introduced into the solvent under a pressure of at least 5 bar.   
     
     
         30 . The method as claimed in  claim 20 , wherein
 the reaction takes place in a continuous-flow reactor.   
     
     
         31 . The method as claimed in  claim 20 , wherein
 the reaction takes place on a microstructure.   
     
     
         32 . The method as claimed in  claim 31 , wherein
 the microstructure comprises at least one microelectrode.   
     
     
         33 . The method as claimed in  claim 31 , wherein
 the microstructure comprises two microelectrodes which are located in an undivided space.   
     
     
         34 . The method as claimed in  claim 31 , wherein
 the microstructure is selected from the group consisting of a coating, a tubular module, a linear element, a two-dimensional lattice, a two-dimensional surface and a three-dimensional mesh.   
     
     
         35 . The method as claimed in  claim 31 , wherein the microstructure comprises:
 a tubular cathode; and   a linear anode arranged centrally inside the cathode, the cathode and the anode being arranged relative to one another such that a longitudinal direction of the cathode runs parallel to a longitudinal direction of the anode.   
     
     
         36 . The method as claimed in  claim 34 , wherein
 the reaction takes place in a rectangular microstructure,   the rectangular microstructure has opposing walls formed respectively of two dimensional surfaces, and   an anode and a cathode are formed respectively in the two-dimensional surfaces.   
     
     
         37 . The method as claimed in  claim 20 , further comprising:
 hydrolyzing a carboxyl group of the carboxylate to produce an acid.   
     
     
         38 . The method as claimed in  claim 20 , further comprising:
 hydrolyzing a carboxyl group of the carboxylate to produce a carboxylic acid; and   isolating the carboxylic acid from the solvent.   
     
     
         39 . A use of radioactively labeled carbon dioxide for the electrochemical synthesis of a radioactively labeled carboxylate, wherein
 the carbon dioxide is completely dissolved in a solvent during synthesis.   
     
     
         40 . A use of a microelectrode for the electrochemical synthesis of a radioactively labeled carboxylate, wherein
 radioactively labeled carbon dioxide is reacted.