Pharmaceutical composition containing as an active ingredient 5-methyl-1-phenyl-2-(1h)-pyridone

Abstract

A tablet characterized by comprising 5-methyl-1-phenyl-2-(1H)-pyridone as the main ingredient and, based on the main ingredient, 10 to 50 wt. % excipient, 5 to 40 wt. % disintegrator, 1 to 10 wt. % binder, 0.5 to 5 wt. % lubricant, 2 to 6 wt. % coating basis, and 0.05 to 3 wt. % light-shielding agent, wherein the odor or bitterness of the 5-methyl-1-phenyl-2-(1H)-pyridone is masked and the light stability is improved.

1 . A tablet containing as the main ingredient 5-methyl-1-phenyl-2-(1H)-pyridone. 
     
     
         2 . A tablet as claimed in  claim 1 , the weight of which is 100 to 1000 mg. 
     
     
         3 . A tablet as claimed in  claim 1  or  2 , which contains 10 to 85 wt. % main ingredient to the weight of the tablet. 
     
     
         4 . A tablet as claimed in any one of  claims 1  to  3 , wherein the content of the main ingredient is 200 mg to 400 mg. 
     
     
         5 . A tablet as claimed in any one of  claims 1  to  4 , which contains a light-shielding agent. 
     
     
         6 . A tablet as claimed in  claim 5 , which contains 0.05 to 3 wt. % shielding agent based on the main ingredient. 
     
     
         7 . A tablet as claimed in any one of  claims 1  to  4 , which contains 10 to 50 wt. % excipient, 5 to 40 wt. % disintegrator, 1 to 10 wt. % binder, 0.5 to 5 wt. % lubricant, 2 to 6 wt. % coating basis, and 0.05 to 3 wt. % light-shielding agent based on the main ingredient. 
     
     
         8 . A tablet as claimed in  claim 7 , which contains 0.01 to 1 wt. % plasticizer based on the main ingredient. 
     
     
         9 . A tablet as claimed in any one of  claims 1  to  4 , which consists of a plain tablet containing 10 to 50 wt. % excipient, 5 to 40 wt. % disintegrator, 1 to 10 wt. % binder, and 0.5 to 5 wt. % lubricant on the main ingredient, and coating layer containing 2 to 6 wt. % coating basis and 0.05 to 3 wt. % light-shielding agent based on the main ingredient. 
     
     
         10 . A tablet as claimed in  claim 9 , which contains 0.01 to 1 wt. % plasticizer based on the main ingredient in a coating layer. 
     
     
         11 . A tablet as claimed in any one of  claims 1  to  4 , which consists of a plain tablet containing 10 to 50 wt. % excipient selected from the group of lactose, corn starch, and crystalline cellulose, 5 to 40 wt. % disintegrator selected from the group of carmellose calcium, low substituted hydroxypropylcellulose, and cross-linked polyvinylpyrrolidone, 1 to 10 wt. % binder selected from the group of hydroxypropylcellulose and polyvinylpyrrolidone, and 0.5 to 5 wt. % lubricant selected from the group of magnesium stearate and talc on the main ingredient, and a coating layer containing 2 to 6 wt. % coating basis selected from the group of hydroxypropylmethylcellulose and hydroxypropylcellulose, 0.01 to 1 wt. % plasticizer selected from the group of triethyl citrate and triacetin, and 0.05 to 3 wt. % light-shielding agent selected from the group of titanium oxide and ferric oxide based on the main ingredient. 
     
     
         12 . A tablet as claimed in  claim 11 , which consists of a plain tablet containing 10 to 50 wt. % lactose, 5 to 40 wt. % carmellose calcium, 1 to 10 wt. % hydroxypropylcellulose, and 0.5 to 5 wt. magnesium stearate on the main ingredient, and a coating layer containing 2 to 6 wt. % hydroxypropylmethylcellulose, 0.01 to 1 wt. % triethyl citrate and 0.05 to 3 wt. % titanium oxide based on the main ingredient. 
     
     
         13 . A tablet as claimed in any one of  claims 1  to  4 , which consists of a plain tablet containing 20 to 30 wt. % excipient selected from the group of lactose, corn starch, and crystalline cellulose, 7.5 to 15 wt. % disintegrator selected from the group of carmellose calcium, low substituted hydroxypropylcellulose, and cross-linked polyvinylpyrrolidone, 2 to 5 wt. % binder selected from the group of hydroxypropylcellulose and polyvinylpyrrolidone, and 0.5 to 3 wt. % lubricant selected from the group of magnesium stearate and talc on the main ingredient, and a coating layer containing 2 to 4 wt. % coating basis selected from the group of hydroxypropylmethylcellulose and hydroxypropylcellulose, 0.01 to 1 wt. % plasticizer selected from the group of triethyl citrate and triacetin, and 0.8 to 3 wt. % titanium oxide as a light-shielding agent based on the main ingredient. 
     
     
         14 . A tablet as claimed in  claim 13 , which consists of a plain tablet containing 20 to 30 wt. % lactose, 7.5 to 15 wt. % carmellose calcium, 2 to 5 wt. % hydroxypropylcellulose, and 0.5 to 3 wt. magnesium stearate on the main ingredient, and a coating layer containing 2 to 4 wt. % hydroxypropylmethylcellulose, 0.01 to 1 wt. % triethyl citrate and 0.8 to 3 wt. % titanium oxide based on the main ingredient.