Integrated disposable set for an apheresis system

Abstract

An integrated pre-connected apheresis disposable set for separating plasma from blood in a separation vessel and further separating the separated plasma into desired plasma proteins in a plasma separator fluidly connected to the separation vessel to receive the separated plasma.

1 . An integrated pre-connected disposable set for an apheresis system comprising
 a removal/return assembly for removing and returning blood and blood components to a donor;   a separation vessel fluidly connected to the removal/return assembly and adapted for mounting on a centrifuge for rotation wherein whole blood is separated in the separation vessel during rotation of the centrifuge into at least plasma and other components;   a plasma collect assembly fluidly connected to the separation vessel to receive separated plasma comprising
 a hollow fiber membrane plasma separator for separating the separated plasma into at least a plasma protein fraction; 
 a collection container fluidly connected to the hollow fiber membrane plasma separator to receive the plasma protein fraction; 
   a plasma return assembly for returning uncollected plasma and any uncollected plasma proteins separated from the collected plasma protein fraction in the hollow fiber membrane plasma separator to the donor; and   a fluid flow cassette having internal passageways for fluidly connecting the separation vessel to the hollow fiber membrane plasma separator, for fluidly connecting the removal/return assembly to the separation vessel and for fluidly connecting the plasma return assembly to the removal/return assembly for return of uncollected plasma and any plasma proteins to the donor.   
     
     
         2 . The disposable set of  claim 1  further comprising an anticoagulant tubing assembly interconnected to the fluid flow cassette for providing anticoagulant to the removed blood. 
     
     
         3 . The disposable set of  claim 1  wherein whole blood is separated in the separation vessel during rotation of the centrifuge into at least plasma and red blood cells and further comprising a red blood cell collection assembly inter-connected to the fluid flow cassette assembly. 
     
     
         4 . The disposable set of  claim 1  further comprising a replacement fluid sub-assembly interconnected to the fluid flow cassette. 
     
     
         5 . The disposable set of  claim 1  wherein the fluid flow cassette comprises a blood return reservoir connected to the plasma return assembly. 
     
     
         6 . The disposable set of  claim 5  further comprising a vent bag tubing sub-assembly interconnected to the blood return reservoir for receiving and returning air thereto.