Combination neisserial compositions

Abstract

Compositions comprising a first biological molecule from a Neisseria bacterium and a second biological molecule from a Neisseria bacterium. The term “biological molecule” includes proteins and nucleic acids. Preferred Neisseria species are N. meningitidis and N. gonorrhoeae.

1 . A composition comprising a first isolated biological molecule from a  Neisseria  bacterium and a second isolated biological molecule from a  Neisseria  bacterium, wherein the first biological molecule is from a first GNA1870 and the second biological molecule is from a second GNA1870, wherein said first biological molecule and said second biological molecule are different. 
     
     
         2 . The composition of  claim 1 , wherein the first biological molecule and the second biological molecule are from  N. meningitidis  and/or  N. gonorrhoeae    
     
     
         3 . The composition of  claim 1 , wherein the first biological molecule and the second biological molecule are from  N. meningitidis.    
     
     
         4 . The composition of  claim 1 , wherein the first biological molecule comprises a first amino acid sequence selected from (i) a sequence having at least 80% sequence identity to SEQ ID NO: 3516; and (ii) 8 or more contiguous amino acids from SEQ ID NO: 3516; and the second biological molecule comprises a second amino acid sequence selected from (a) a sequence having at least 80% sequence identity to SEQ ID NO: 3518; (b) 8 or more contiguous amino acids from SEQ ID NO: 3518, (c) a sequence having at least 80% sequence identity to SEQ ID NO: 3520; and (d) 8 or more contiguous amino acids from SEQ ID NO: 3520. 
     
     
         5 . The composition of  claim 4 , wherein the first amino acid sequence is the sequence having at least 80% sequence identity to SEQ ID NO: 3516; and the second amino acid sequence is selected from (a) a sequence having at least 80% sequence identity to SEQ ID NO: 3518; and (b) a sequence having at least 80% sequence identity to SEQ ID NO: 3520. 
     
     
         6 . The composition of  claim 4 , wherein the first amino acid sequence is 8 or more contiguous amino acids from SEQ ID NO: 3516; and the second amino acid sequence is selected from (a) 8 or more contiguous amino acids from SEQ ID NO: 3518, and (b) 8 or more contiguous amino acids from SEQ ID NO: 3520. 
     
     
         7 . The composition of  claim 1 , wherein the first biological molecule comprises a first amino acid sequence selected from (i) a sequence having at least 80% sequence identity to SEQ ID NO: 3518; and (ii) 8 or more contiguous amino acids from SEQ ID NO: 3518; and the second biological molecule comprises a second amino acid sequence selected from (a) a sequence having at least 80% sequence identity to SEQ ID NO: 3516; (b) 8 or more contiguous amino acids from SEQ ID NO: 3516, (c) a sequence having at least 80% sequence identity to SEQ ID NO: 3520; and (d) 8 or more contiguous amino acids from SEQ ID NO: 3520. 
     
     
         8 . The composition of  claim 7 , wherein the first amino acid sequence is the sequence having at least 80% sequence identity to SEQ ID NO: 3518; and the second amino acid sequence is selected from (a) a sequence having at least 80% sequence identity to SEQ ID NO: 3516; and (b) a sequence having at least 80% sequence identity to SEQ ID NO: 3520. 
     
     
         9 . The composition of  claim 7 , wherein the first amino acid sequence is 8 or more contiguous amino acids from SEQ ID NO: 3518; and the second amino acid sequence is selected from (a) 8 or more contiguous amino acids from SEQ ID NO: 3516, and (b) 8 or more contiguous amino acids from SEQ ID NO: 3520. 
     
     
         10 . The composition of  claim 1 , wherein the first biological molecule comprises a first amino acid sequence selected from (i) a sequence having at least 80% sequence identity to SEQ ID NO: 3520; and (ii) 8 or more contiguous amino acids from SEQ ID NO: 3520; and the second biological molecule comprises a second amino acid sequence selected from (a) a sequence having at least 80% sequence identity to SEQ ID NO: 3518; (b) 8 or more contiguous amino acids from SEQ ID NO: 3518, (c) a sequence having at least 80% sequence identity to SEQ ID NO: 3516; and (d) 8 or more contiguous amino acids from SEQ ID NO: 3516. 
     
     
         11 . The composition of  claim 10 , wherein the first amino acid sequence is the sequence having at least 80% sequence identity to SEQ ID NO: 3520; and the second amino acid sequence is selected from (a) a sequence having at least 80% sequence identity to SEQ ID NO: 3518; and (b) a sequence having at least 80% sequence identity to SEQ ID NO: 3516. 
     
     
         12 . The composition of  claim 10 , wherein the first amino acid sequence is 8 or more contiguous amino acids from SEQ ID NO: 3520; and the second amino acid sequence is selected from (a) 8 or more contiguous amino acids from SEQ ID NO: 3518, and (b) 8 or more contiguous amino acids from SEQ ID NO: 3516. 
     
     
         13 . The composition of any one of  claims 1 - 12  further comprising an adjuvant. 
     
     
         14 . The composition of  claim 6 , wherein the first amino acid sequence further comprises an epitope from SEQ ID NO: 3516; and the second biological molecule further comprises an epitope from SEQ ID NO: 3518, when the second amino acid is 8 or more contiguous amino acids from SEQ ID NO: 3518, or the second biological molecule further comprises an epitope from SEQ ID NO: 3520, when the second amino acid is 8 or more contiguous amino acids from SEQ ID NO: 3520. 
     
     
         15 . The composition of  claim 9 , wherein the first amino acid sequence further comprises an epitope from SEQ ID NO: 3518; and the second biological molecule further comprises an epitope from SEQ ID NO: 3516, when the second amino acid is 8 or more contiguous amino acids from SEQ ID NO: 3516, or the second biological molecule further comprises an epitope from SEQ ID NO: 3520, when the second amino acid is 8 or more contiguous amino acids from SEQ ID NO: 3520. 
     
     
         16 . The composition of  claim 12 , wherein the first amino acid sequence further comprises an epitope from SEQ ID NO: 3520; and the second biological molecule further comprises an epitope from SEQ ID NO: 3518, when the second amino acid is 8 or more contiguous amino acids from SEQ ID NO: 3518, or the second biological molecule further comprises an epitope from SEQ ID NO: 3516, when the second amino acid is 8 or more contiguous amino acids from SEQ ID NO: 3516.