Cyanoacrylate Adhesive Compositions, Methods of Sterilization of the Compositions, and Articles of Manufacture Containing Such Compositions

Abstract

Adhesive 2-cyanoacrylate compositions are adjusted to a preferred initial viscosity of 400 to 600 centipoises by the addition of polycyanoacrylate thickeners, and are sterilized in a preferred method by heating them at a temperature of no greater than about 110° C. for no more than about 120 minutes. Articles of manufacture are vials or squeezable tubes made of compatible glass, aluminum, or plastic.

1 . A cyanoacrylate adhesive composition, comprising:
 at least one 2-cyanoacrylate monomer; and   at least one polymeric thickener homologous to at least one of the monomers in an amount establishing an initial viscosity that will not increase when the composition is sterilized at a temperature no greater than approximately 110° C. for a period of time sufficient to sterilize the composition.   
     
     
         2 . The composition of  claim 1 , in which:
 said initial viscosity is in the range of about 400 to about 600 centipoises.   
     
     
         3 . The composition of  claim 1 , in which:
 said period of time is no greater than about 120 minutes.   
     
     
         4 . A method of sterilization of a composition of  claim 1 , comprising the steps of:
 (a) placing the composition in a container;   (b) sealing the container; and   (c) heating the composition in the container at a temperature of no greater than approximately 110° C. for a period of time sufficient to sterilize the composition.   
     
     
         5 . The method of  claim 4 , in which:
 said period of time is no greater than about 120 minutes.   
     
     
         6 . The method of  claim 4 , in which:
 said container is comprised of a material taken from the list of:   (a) type I glass;   (b) aluminum; and   (c) plastic.   
     
     
         7 . A method of sterilization of a 2-cyanoacrylate adhesive composition comprising the steps of:
 (a) placing in a container comprised of type I glass at least one 2-cyanoacrylate monomer with at least one polymeric thickener homologous to at least one of the monomers, establishing an initial viscosity that will not increase when the composition is sterilized at a temperature no greater than approximately 110 ° C.;   (b) sealing the container; and   (c) heating the composition in the container at a temperature of no greater than approximately 110 ° C. for a period of time sufficient to sterilize the composition.   
     
     
         8 . The method of  claim 7 , further comprising, between said steps (a) and (b), the additional steps of:
 (a)(1) dissolving approximately 100 to 1000 ppm by weight of SO 2  and approximately 100 to 10,000 ppm by weight of butylated hydroxyanisole (BHA) in the composition; and   (a)(2) dissolving up to approximately 50% by weight of plasticizer in the resulting liquid.   
     
     
         9 . The method of  claim 8 , in which:
 said initial viscosity is in the range of about 400 to about 600 centipoises.   
     
     
         10 . A method of sterilization of a 2-cyanoacrylate adhesive composition comprising the steps of:
 (a) placing in a container comprised of aluminum at least one 2-cyanoacrylate monomer with at least one polymeric thickener homologous to at least one of the monomers, establishing an initial viscosity that will not increase when the composition is sterilized at a temperature no greater than approximately 110 ° C.;   (b) sealing the container; and   (c) heating the composition in the container at a temperature of no greater than approximately 110 ° C. for a period of time sufficient to sterilize the composition.   
     
     
         11 . The method of  claim 10 , further comprising, between said steps (a) and (b), the additional steps of:
 (a)(1) dissolving approximately 100 to 1000 ppm by weight of SO 2  and approximately 100 to 10,000 ppm by weight of butylated hydroxyanisole (BHA) in the composition; and   (a)(2) dissolving up to approximately 50% by weight of plasticizer in the resulting liquid.   
     
     
         12 . The method of  claim 11 , in which:
 said initial viscosity is in the range of about 400 to about 600 centipoises.   
     
     
         13 . A method of sterilization of a 2-cyanoacrylate adhesive composition comprising the steps of:
 (a) placing in a container comprised of plastic at least one 2-cyanoacrylate monomer with at least one polymeric thickener homologous to at least one of the monomers, establishing an initial viscosity that will not increase when the composition is sterilized at a temperature no greater than approximately 110 ° C.;   (b) sealing the container; and   (c) heating the composition in the container at a temperature of no greater than approximately 110 ° C. for a period of time sufficient to sterilize the composition.   
     
     
         14 . The method of  claim 13 , further comprising, between said steps (a) and (b), the additional steps of:
 (a)(1) dissolving approximately 100 to 1000 ppm by weight of SO 2  and approximately 100 to 10,000 ppm by weight of butylated hydroxyanisole (BHA) in the composition; and   (a)(2) dissolving up to approximately 50% by weight of plasticizer in the resulting liquid.   
     
     
         15 . The method of  claim 14 , in which:
 said initial viscosity is in the range of about 400 to about 600 centipoises.   
     
     
         16 . An article of manufacture, comprising:
 a container packed with a mixture of about 3.5% by weight of polyoctyl-2-cyanoacrylate, about 100 ppm SO 2 , and about 1000 ppm butylated hydroxyanisole (BHA), all dissolved in the balance percentage by weight of octyl-2-cyanoacrylate monomer, then sealed; and   the sealed vial heated to a temperature of between about 100° C. and about 110° C. for a period of time between about 60 minutes and 120 minutes, establishing a sterile adhesive having a viscosity of in the range of about 400 centipoises to about 600 centipoises.   
     
     
         17 . The article of manufacture of  claim 16 , in which:
 said container is comprised of a material taken from the list of:   (a) type I glass;   (b) aluminum; and   (c) plastic.