Gene Signature for Diagnosis and Prognosis of Breast Cancer and Ovarian Cancer

Abstract

A first embodiment is a breast cancer prognosticator comprising a detection mechanism consisting a 15-gene signature. In addition there are embodiments comprised of 23-gene signatures and 28-gene signatures. The 28-gene signature may also be used for the prognosis of ovarian cancer. Another embodiment is a method to determine relapse free potential in breast cancer patients comprising collecting a sample from an individual, removing marker-derived polynucleotide from said sample, using a detection mechanism to search for positive matches of said polynucleotides and a 24-gene signature, and developing a quantitative expression profile.

1 . A gene signature comprising nucleic acids wherein the nucleic acids consist of Seq. ID No. 8-12, 16-24, 26, 27, 29, 31, 32, 42-44 wherein the nucleic acids are a breast cancer relapse and metastatic potential prognosticator. 
     
     
         2 . The gene signature of  claim 1  wherein the nucleic acids further consist of Seq. ID No. 3, 7, 13-15, 25, 30, 33, 34-41.