Dual-chamber carpule

Abstract

The invention relates to a dual-chamber carpule having a first partial cylinder comprising a sealing cap, a bypass, and an intermediate stopper, an optional sealing element, and a second partial cylinder comprising an end stopper and, optionally, a stop, an axial groove, and an additional intermediate stopper; the invention further relates to a method for producing and filling said dual-chamber carpule.

1 - 15 . (canceled) 
     
     
         16 . A two-chamber carpule for use with an application system comprising:
 a) a first part-cylinder having a proximal end and a distal end, the first part-cylinder forming a first chamber comprising,
 a needle pierceable closure at the distal end, 
 a bypass, 
 an opening for receiving an intermediate plug at the proximal end, and 
 an intermediate plug slidably positioned in the opening of the proximal end; and 
   b) a second part-cylinder having a proximal end and a distal end, the second part-cylinder forming a second chamber comprising,
 an opening at the distal end, 
 an opening for receiving an end plug at the proximal end, and 
 an end plug slidably positioned in the opening of the proximal end; 
   wherein one or both of the proximal end of the first part cylinder and the distal end of the second part-cylinder are configured to prevent pressure build-up in the second chamber when the first part-cylinder and the second part-cylinder are joined together during assembly, where the resulting assembly is configured to be inserted and installed into an application system.   
     
     
         17 . The two-chamber carpule of  claim 16  where the first chamber contains a solid and the second chamber contains a liquid. 
     
     
         18 . The two-chamber carpule of  claim 16  where the first chamber contains a liquid and the second chamber contains a liquid. 
     
     
         19 . The two-chamber carpule of  claim 16  where a sealing element is positioned between the first part-cylinder and the second part cylinder. 
     
     
         20 . The two-chamber carpule of  claim 16  where the proximal end of the first part-cylinder and the distal end of the second part-cylinder are configured to form a closure selected from the group consisting of a screw, adhesive, snap and a combination of such closures. 
     
     
         21 . The two-chamber carpule of  claim 20  where the first part-cylinder and the second part-cylinder are comprised of plastic. 
     
     
         22 . The two-chamber carpule of  claim 16  where the proximal end of the second part-cylinder has a stop. 
     
     
         23 . An application system to deliver medicament comprising,
 a. the two-chamber carpule of claim  1 ; and   b. a drive mechanism for moving the end plug in the distal direction.