Self-Neutralizing Acid Peel for Dermatologic Use

Abstract

A dermatologic peel comprising alpha hydroxyl acid and metal hydroxide nanocomplexes as neutralizing agents to continually reduce the activity of the system when the acid and neutralizer components are mixed. For example, a 30% glycolic acid gel mixed with a fluidized magaldrate neutralizer can be applied to the skin and will self-neutralize to a skin-compatible pH within a few minutes, effectively exfoliating the skin without a separate neutralization step. The peel is advantageously applied from a two-component system that mixes the components.

1 . A two-component system for preparing a self-neutralizing dermatologic peel composition by mixing the components prior to application to the skin, said system comprising:
 a first container of at least one alpha hydroxy acid component; and   a second container of neutralizer component, said neutralizer component comprising at least one insoluble inorganic metal hydroxide;   wherein the acid component is characterized by establishing an initial free acid concentration efficacious for a dermatologic peel upon first mixing with the neutralizer component prior to application to the skin, and the neutralizer component is characterized by reducing the initial free acid concentration of the composition while applied to the skin at a rate sufficient to increase the pH of the composition to a substantially skin-compatible composition and substantially stop the exfoliation in a predetermined treatment time.   
     
     
         2 . The system of  claim 1  wherein said inorganic metal hydroxide is aluminum hydroxide.