Angiogenesis regulating composition and method for regulating angiogenesis

Abstract

An angiogenesis regulating composition used to treat/prevent an angiogenic disease in a subject, that contains in an effective amount at least one of nitrate, nitrite, and a compound convertible into nitrate or nitrite after the compound is absorbed into the subject, and an angiogenesis regulation method administering to a subject a composition containing as an active ingredient at least one of nitrate. nitrite, and a compound convertible into nitrate or nitrite after the compound is absorbed into the subject, provide a composition effective in treating and preventing angiogenic diseases, that can medically control angiogenic diseases, and medically regulate angiogenesis in ophthalmologic diseases in particular, and allows treatment without inhibiting physiological neovascularization, with a limited side effect and significantly safely, and an angiogenesis regulation method using the same.

1 . An angiogenesis regulating composition used to treat/prevent an angiogenic disease in a subject, the composition containing in an effective amount at least one of nitrate, nitrite, and a compound convertible into one of nitrate and nitrite after said compound is absorbed into the subject. 
     
     
         2 . The composition according to  claim 1 , regulating angiogenesis by maintaining a nitrate ion concentration in an effective concentration range in the subject. 
     
     
         3 . The composition according to  claim 1 , containing at least one of nitrate, nitrite, and said compound in an amount providing a plasma concentration of nitrate ions within a range of 8 μmol/L to 1000 μmol/L when the composition is administered to the subject. 
     
     
         4 . The composition according to  claim 1 , wherein said angiogenic disease is at least one ophthalmologic disease selected from retinopathy of prematurity, diabetic retinopathy, age-related macular degeneration, and neovascular glaucoma. 
     
     
         5 . The composition according to  claim 1 , being a pharmaceutical composition. 
     
     
         6 . The composition according to  claim 1 , being at least one selected from health food, functional food, food for specified health use, and dietary supplement. 
     
     
         7 . An angiogenesis regulation method administering to a subject a composition containing as an active ingredient at least one of nitrate, nitrite, and a compound convertible into one of nitrate and nitrite after said compound is absorbed into the subject. 
     
     
         8 . The method according to  claim 7 , regulating angiogenesis by maintaining a nitrate ion concentration in an effective concentration range in the subject. 
     
     
         9 . The method according to  claim 7 , providing a plasma concentration of nitrate ions in the subject within a range of 8 μmol/L to 1000 μmol/L.