Composition of extract of emblica officinalis and method of preparing the same

Abstract

The present disclosure relates to a composition of an extract of fruits of Emblica officinalis selected from the group consisting of liquid juice of fruits of Emblica officinalis , a powder of an alcoholic extract of fruits of Emblica officinalis , a powder of a hydro alcoholic extract of fruits of Emblica officinalis , a powder of a water extract of fruits of Emblica officinalis , a powder of a juice of fruits of Emblica officinalis , a powder of dried fruits of Emblica officinalis , a powder of a water extract of dried fruits of Emblica officinalis , a powder of a pectinase treated water extract of fruits of Emblica officinalis , and combinations thereof; a method of preparing such compositions of extract of fruits of Emblica officinalis , more particularly which has application as a nutraceutical or pharmaceutical for increasing HDL-C levels in patients with memory loss and dementia especially in patients with neurodegenerative diseases like Alzheimer's disease and for the treatment of memory loss especially in Alzheimer's disease.

1 . An extract of fruits of  Emblica officinalis  selected from the group consisting of a liquid juice of fruits of  Emblica officinalis , a powder of an alcoholic extract of fruits of  Emblica officinalis , a powder of a hydroalcoholic extract of fruits of  Emblica officinalis , a powder of a water extract of fruits of  Emblica officinalis , a powder of a juice of fruits of  Emblica officinalis , a powder of dried fruits of  Emblica officinalis , a powder of a water extract of dried fruits of  Emblica officinalis , and, a powder of a pectinase treated water extract of fruits of  Emblica officinalis.    
     
     
         2 . The extract of fruits of  Emblica officinalis  of  claim 1 , comprising about 12% to 70% polyphenols. 
     
     
         3 . The extract of fruits of  Emblica officinalis  of  claim 1 , comprising about 5% to about 35% hydrolysable gallo ellagic tannins. 
     
     
         4 . A dosage form comprising the extract of fruits of  Emblica officinalis  as claimed in  claim 1 , wherein the dosage form selected from the group consisting of a capsule, tablet, granule, sachet, powder, paste, ointment, infusion, injection, ampoule, solution, suspension, emulsion, pill, sustained release formulation and combinations thereof. 
     
     
         5 . A method of preparing a liquid juice of  Emblica officinalis  comprising:
 crushing fresh fruits of  Emblica officinalis  to obtain an initial juice;   separating an initial filtrate and a residue from the initial juice;   rotating the initial filtrate in a rotating disc type clarifier to obtain a final filtrate and a final residue;   removing the final residue from the final filtrate to generate the liquid juice of  Emblica officinalis.      
     
     
         6 . A method of preparing a powder of an alcoholic extract of fruits of  Emblica officinalis  comprising:
 pulverizing raw fruits of  Emblica officinalis  to obtain a pulp;   charging the pulp into an extractor, adding 95% alcohol into the extractor and incubating with the pulp for 3 hours to obtain an alcohol supernatant and a residue;   removing the alcohol supernatant from the extractor;   filtering the alcohol supernatant to obtain a filtered alcohol supernatant;   drying the filtered alcohol supernatant in an agitated thin film drier under a vacuum of about 600 to about 700 mm mercury to obtain a dried alcohol supernatant;   pulverizing the dried alcohol supernatant to obtain a pulverized alcohol supernatant;   sieving the pulverized alcohol supernatant to obtain the powder of the alcoholic extract of the fruits of  Emblica officinalis.      
     
     
         7 . A method of preparing a powder of a hydroalcoholic extract of fruits of  Emblica officinalis  by a process comprising:
 pulverizing raw fruits of  Emblica officinalis  to obtain a pulp;   charging the pulp into an extractor, adding an alcohol: water mixture to the extractor, incubating for 3 hours to form a hydroalcoholic supernatant and a residue;   collecting the hydroalcoholic supernatant;   filtering the supernatant to obtain a filtered hydroalcoholic supernatant;   concentrating the filtered hydroalcoholic supernatant to obtain a concentrated hydroalcoholic supernatant; and,   drying the concentrated hydroalcoholic supernatant to obtain the powder of the hydroalcoholic extract of fruits of  Emblica officinalis.      
     
     
         8 . A method of preparing a powder of a water extract of fruits of  Emblica officinalis  by a process comprising:
 pulverizing raw fruits of  Emblica officinalis  to obtain a pulp;   charging the pulp into an extractor, adding water to the pulp in the extractor, incubating the water and the pulp for 3 hours to obtain a water supernatant and a residue;   removing the water supernatant from the extractor;   filtering the water extract to obtain a filtered water extract;   concentrating the filtered water extract to obtain a concentrated water extract; and,   drying the concentrated water extract to obtain the powder of the water extract of fruits of  Emblica officinalis      
     
     
         9 . A method of preparing a powder of a juice extract of fruits of  Emblica officinalis  by a process comprising:
 crushing fresh fruits of  Emblica officinalis  to obtain an initial juice;   centrifuging the initial juice to obtain an initial filtrate and an initial residue;   separating the initial filtrate from the initial residue to obtain a separated initial filtrate;   clarifying the separated initial filtrate to obtain a final filtrate and a final residue;   separating the final filtrate from the final residue to obtain a separated final filtrate;   drying the final filtrate to obtain a dried powder; and,   sieving the dried powder to obtain the powder of the juice of fruits of  Emblica officinalis.      
     
     
         10 . A method of preparing a powder of dried fruits of  Emblica officinalis  by a process comprising:
 chopping fresh fruits of  Emblica officinalis  to obtain flakes of fruits of  Emblica officinalis;      drying the flakes of fruits of  Emblica officinalis  at 110° C. for about 10 hours to obtain dried flakes of fruits of  Emblica officinalis;      powdering the dried flakes to obtain a powder;   sterilizing the powder to obtain a sterilized powder;   sieving the sterilized powder through a 30 mesh sieve to obtain the powder of dried fruits of  Emblica officinalis.      
     
     
         11 . A method of preparing a powder of a water extract of dried fruits of  Emblica officinalis  by a process comprising:
 chopping fresh fruits of  Emblica officinalis  to obtain flakes of fruits of  Emblica officinalis;      drying the flakes of fruits of  Emblica officinalis  at 110° C. for about 10 hours to obtain dried flakes of fruits of  Emblica officinalis;      adding water to the dried flakes of fruits of  Emblica officinalis , incubating for 3 hours to obtain a water supernatant and a residue;   separating the water supernatant from the residue to obtain a separated water supernatant;   filtering the separated water supernatant to obtain a filtered water supernatant;   concentrating the filtered water supernatant to obtain a concentrated water supernatant;   drying the concentrated water supernatant in a vacuum stripper under vacuum at about 500 mm mercury to obtain a dried water supernatant;   pulverizing the dried water supernatant to obtain a pulverized dried water supernatant; and,   sieving the pulverized dried water supernatant to obtain the powder of the water extract of the dried fruits of  Emblica officinalis.      
     
     
         12 . A method of preparing a powder of a pectinase treated water extract fruits of  Emblica officinalis  by a process comprising:
 pulping fruits of  Emblica officinalis  with demineralized water to create a slurry;   treating the slurry with pectinase;   filtering the slurry to obtain a solution;   concentrating the solution to obtain a concentrate; and,   drying the concentrate under vacuum to generate the powder of the pectinase treated water extract fruits of  Emblica officinalis.      
     
     
         13 . A method of increasing HDL cholesterol levels in a patient in need thereof, comprising administering an extract of fruits of  Emblica officinalis  as claimed in  claim 1 . 
     
     
         14 . The method as claimed in  claim 13 , wherein the patient is selected from the group consisting of a patient having memory loss, a patient having Alzheimer's, and combinations thereof.