Compositions and methods for treating, inhibiting the onset, and slowing the progression of erectile dysfunction including naturally occuring age related erectile dysfunction

Abstract

Compositions for treating erectile dysfunction (“ED”), including age related erectile dysfunction (ARED), comprise in a preferred embodiment ginger and an amino acid. Preferably the amino acid is L-arginine and/or L-citrulline. Additionally, the compositions may comprise cortex magnoliae officinalis (CMO) and/or fructus aurantil immaturus (FAI). The compositions of the present inventions are administered in a pharmaceutically effective amount to treat erectile dysfunction. For patients that have noticeable symptoms of ED or for older males, whether or not symptomatic, preferred compositions comprises ginger, L-arginine and/or L-citrulline, CMO, FAI, Paullinia cupana, and Muira puama.

1 . A composition comprising at least a first and at least a second compound, wherein said first compound is ginger and said second compound is selected from the group consisting of L-arginine and a compound that produces L-arginine in vivo, wherein administration of a pharmaceutically effective amount of said composition will treat erectile dysfunction by halting, slowing or reversing the deterioration of smooth muscle cells of the corporal cavernosum, wherein at least a portion of said ginger can be replaced with gingerol, wherein essential for said composition to treat erectile dysfunction are said ginger or said gingerol and said L-arginine or compound that produces L-arginine in vivo, wherein said composition comprises at least 250 mg ginger or an amount of gingerol sufficient to achieve the same effect in treating erectile dysfunction, and said composition comprises at least about 500 mg L-arginine, wherein said L-arginine can be in addition to or replaced by an amount of L-citrulline sufficient to produce substantially the same effect in vivo as said at least 500 mg of L-arginine, and wherein said composition is effective in treating erectile dysfunction without any other ingredients, and wherein the effective ingredients in said composition for treating erectile dysfunction consist essentially of said ginger, said gingerol, a combination of said ginger and said gingerol, said L-arginine, said L-citrulline or a combination of said L-arginine and said L-citrulline, and at least one compound selected from the group consisting of cortex magnoliae officinalis, fructus aurantil immaturus,  Paullinia cupana,  and  Muira puama.    
     
     
         2 . The composition of  claim 1 , wherein a dose of said composition can be administered periodically to a subject for a sufficient period of time until erectile dysfunction is treated in the subject, and wherein the active ingredients in said composition for the treatment of erectile dysfunction consist essentially of said ginger, said gingerol, said  Paullinia cupana,  said  Muira puama,  and at least one of said L-arginine and said L-citrulline. 
     
     
         3 . The composition of  claim 2 , wherein said composition comprises at least about 50 mg  Muira puama.    
     
     
         4 . The composition of  claim 1 , wherein said composition active ingredients for treating erectile dysfunction consist essentially of at least 250 mg ginger, at least 10 mg L-Citrulline, wherein when said composition contains no L-arginine a sufficient amount of L-Citrulline is present to have the equivalent in vivo effect as said L-arginine, at least about 50 mg  Muira puama,  and  Paullinia cupana.    
     
     
         5 . A composition comprising a first and a second compound, wherein said first compound is ginger and said second compound is L-citrulline, wherein administration of a pharmaceutically effective amount of said composition will treat erectile dysfunction by halting, slowing or reversing the deterioration of smooth muscle cells of the corporal cavernosum, wherein said composition comprises at least 250 mg ginger or an amount of gingerol sufficient to achieve the same effect in treating erectile dysfunction, and wherein said composition can include as active ingredients to treat erectile dysfunction at least one of the group consisting of  Muira Puama  and  Paullinia cupana,  wherein ingredients in said composition essential to the treatment of erectile dysfunction consist essentially of said ginger and said L-citrulline, and wherein said essential ingredients can include compounds selected from the group consisting of one of the group consisting of  Muira Puama  and  Paullina cupana.    
     
     
         6 . The composition of  claim 5 , wherein said composition comprises between at least 250 mg ginger and about 2 grams of ginger and further comprises 500 mg L-citrulline and 3 grams L-citrulline. 
     
     
         7 . (canceled) 
     
     
         8 . (Canceled) 
     
     
         9 . (canceled) 
     
     
         10 . A method of diagnosing and treating erectile dysfunction by evaluation of smooth muscle cell of the corpora cavernosa, and providing a pharmaceutically effective amount of a composition comprising ginger and L-citrulline or L-arginine. 
     
     
         11 . A method for treating erectile dysfunction, comprising the steps of administering to a patient an effective amount of a composition comprising ginger and L-arginine or a compound that produces L-arginine in vivo. 
     
     
         12 . The method of  claim 9 , further comprising repeating administering said composition to said patient over a period of time. 
     
     
         13 . The method of  claim 13 , wherein said composition is taken as a prophylaxis against erectile dysfunction.