Combination pressure therapy for treatment of ischemia and heart conditions, diabetes, alzheimer's disease and cancer

Abstract

Methods for administering pressure changes to a user for the treatment and prevention of diseases and conditions are disclosed herein. Methods of administering Cyclic Variations in Altitude Conditioning Sessions (CVAC Session(s)) for the treatment of ischemia, diabetes and associated complications, Alzheimer's disease, and cancer are disclosed herein.

1 . A method, comprising:
 administering at least two CVAC (Cyclic Variations in Altitude Condition) sessions to a mammal in a pressure vessel unit, the at least two CVAC sessions each having a duration of 20 minutes, and including a start point of ambient pressure at the delivery site, an end point of ambient pressure at the delivery site, and a plurality of atmospheric pressure targets executed between the start point and said end point; and   measuring at least one physiological marker associated with the mammal prior to the administering.   
     
     
         2 . The method of  claim 1 , wherein the administering is configured to treat at least one complication associated with diabetes in the mammal, the at least one complication including at least one of diabetic ulcerations, vascular disease, heart disease, visual disorders, or kidney disease. 
     
     
         3 . The method of  claim 1 , further comprising:
 measuring the at least one physiological marker associated with the mammal after the administering.   
     
     
         4 . The method of  claim 3 , further comprising:
 measuring an efficacy of the at least two CVAC sessions based on a change to the at least one physiological marker associated with the mammal prior to and after the administering.   
     
     
         5 . The method of  claim 1 , wherein the at least one physiological marker includes at least one of insulin, HbA1c, glucose tolerance, glucose transport, GLUT expression, HIF-1α expression, VEGF production, hematocrit, erythropoietin production, oxygenation of tissues in the mammal, or angiogenesis within tissues of the mammal. 
     
     
         6 . The method of  claim 1 , further comprising:
 administering at least one pharmaceutical compound.   
     
     
         7 . The method of  claim 5 , wherein the pharmaceutical compound is insulin. 
     
     
         8 . The method of  claim 1 , wherein each of the plurality of pressure targets is equivalent to a pressure in a range of 2,000 ft and 22,500 ft above atmospheric pressure. 
     
     
         9 . The method of  claim 1 , wherein each of the plurality of pressure targets is equivalent to a pressure in a range of 1,000 ft and 11,000 ft above atmospheric pressure.