US2012035113A1PendingUtilityA1

Methods of reducing trail-induced apoptosis by trail isoforms

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Individually held — no corporate assignee on recordPriority: Aug 4, 2006Filed: Jul 25, 2011Published: Feb 9, 2012
Est. expiryAug 4, 2026(~0 yrs left)· nominal 20-yr term from priority
Inventors:Andrew D. BadleyGary D. BrenDavid J. Schnepple
A61P 35/00A61P 43/00A61P 3/10A61P 31/18A61P 1/16A61P 13/08C07K 14/70575A61K 2039/505C07K 2319/30
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Claims

Abstract

This document provides to methods and materials related to apoptosis. For example, methods and materials for modulating apoptosis are provided. In addition, methods and materials for treating a mammal having an apoptosis-associated condition are provided.

Claims

exact text as granted — not AI-modified
1 . A method for treating a mammal in need of reduced TRAIL-induced apoptosis, said method comprising administering to said mammal an effective amount of a substantially pure polypeptide comprising a sequence having at least 80 percent identity to the sequence set forth in SEQ ID NO:1. 
     
     
         2 . The method of  claim 1 , wherein said mammal is a human. 
     
     
         3 . The method of  claim 1 , wherein said polypeptide comprising a sequence having at least 85 percent identity to the sequence set forth in SEQ ID NO:1. 
     
     
         4 . The method of  claim 1 , wherein said polypeptide comprising a sequence having at least 90 percent identity to the sequence set forth in SEQ ID NO:1. 
     
     
         5 . The method of  claim 1 , wherein said polypeptide comprising a sequence having at least 95 percent identity to the sequence set forth in SEQ ID NO:1. 
     
     
         6 . The method of  claim 1 , wherein said polypeptide comprising a sequence having at least 98 percent identity to the sequence set forth in SEQ ID NO:1. 
     
     
         7 . The method of  claim 1 , wherein said polypeptide comprising a sequence having at least 99 percent identity to the sequence set forth in SEQ ID NO:1. 
     
     
         8 . A method for treating a mammal in need of reduced TRAIL-induced apoptosis, said method comprising administering to said mammal an effective amount of a substantially pure polypeptide, wherein said polypeptide is encoded by a nucleic acid that hybridizes, under hybridization conditions, to the sense or antisense strand of a nucleic acid having the sequence set forth in SEQ ID NO:4. 
     
     
         9 . The method of  claim 8 , wherein said mammal is a human. 
     
     
         10 . The method of  claim 8 , wherein said hybridization conditions are moderately stringent hybridization conditions. 
     
     
         11 . The method of  claim 8 , wherein said hybridization conditions are highly stringent hybridization conditions.

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