US2012028829A1PendingUtilityA1

Anti-hedgehog antibodies

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Individually held — no corporate assignee on recordPriority: Dec 28, 2007Filed: Aug 24, 2011Published: Feb 2, 2012
Est. expiryDec 28, 2027(~1.4 yrs left)· nominal 20-yr term from priority
Inventors:Suzanna J. Scales
C07K 16/18A61P 37/04A61P 35/00G01N 33/57595G01N 33/57545G01N 33/57535
45
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Claims

Abstract

The invention relates to anti-hedgehog antibodies, their use in the detection of hedgehog expression in tissue, and to the use of such detection in the treatment of cancer.

Claims

exact text as granted — not AI-modified
1 . A method for identifying tumors responsive to hedgehog antagonists, comprising contacting the tumor tissue or tissue proximal to the tumor with an anti-hedgehog antibody wherein said anti-hedgehog antibody binds human sonic hedgehog at an epitope contained with the region of the protein having the amino acid sequence of amino acids 75-96 of SEQ ID NO: 16 and determining if hedgehog is overexpressed in said tissue, compared to normal tissue. 
     
     
         2 . The method of  claim 1 , wherein the tumor or tissue is removed from the host prior to the determination. 
     
     
         3 . The method of  claim 2 , wherein the tissue sample is formalin-fixed paraffin-embedded (FFPE) prior to contacting with the antihedgehog antibody. 
     
     
         4 . The method of  claim 2 , wherein the determination method is selected from the group consisting of immunohistochemistry (IHC) and Western blot. 
     
     
         5 . The method of  claim 2  wherein the antibody does not compete with patch for binding to sonic hedgehog (Shh).

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