Use of plasma membrane calcium atpase (pmca) inhibitors to inhibit sperm mobility

Abstract

The invention relates to the use of plasma membrane calcium ATPase (PMCA) inhibitors for inhibiting sperm mobility to achieve a contraceptive effect. The invention further relates to contraceptive agents comprising one or more PMCA inhibitors.

1 . A method of achieving contraception comprising:
 administering a composition comprising an inhibitor that specifically binds to a plasma membrane calcium ATPase 4 (PMCA4) isoform in sperm to effectively suppress sperm mobility.   
     
     
         2 . The method according to  claim 1 , wherein the composition comprises an intracellular-acting inhibitor or an extracellular-acting inhibitor or a combination thereof. 
     
     
         3 . The method according to  claim 2 , wherein the composition comprises one or more inhibitors selected from the group consisting of a 5-carboxyeosindiacetate succinimidyl ester, a 6-carboxyeosindiacetate succinimidyl ester, an eosin, a fluorescein, Caloxin-2A1 and spermin. 
     
     
         4 . The method according to  claim 1 , wherein administering the composition is carried out orally, parenterally or as a coating on a mechanical contraceptive, or in the form of a cream, a gel, or an oil. 
     
     
         5 . The method according to  claim 1 , wherein administering the composition is performed as a single contraceptive dose or as a repeated contraceptive dose. 
     
     
         6 . The method according to  claim 1 , wherein the composition is administered to a mammal. 
     
     
         7 . The method according to  claim 6 , wherein the mammal is a human being. 
     
     
         8 . A contraceptive formulation comprising the composition of  claim 1  and a pharmaceutically acceptable carrier. 
     
     
         9 . The contraceptive formulation according to  claim 8 , wherein the contraceptive composition is administered with a conventional contraceptive. 
     
     
         10 . The contraceptive formulation according to  claim 9 , wherein the conventional contraceptive is a condom, a mechanical contraceptive device, or a spermicidal preparation.