Method of treating osteoporosis

Abstract

A method for treating osteoporosis and related methods are disclosed. The methods generally comprise administering to a patient in need of treatment an effective amount of tris(8-quinolinolato)gallium(III) or an analog thereof.

1 . A method of reducing osteoclastic bone resorption in a patient, comprising administering to the patient an effective amount of a compound according to Formula (I) 
       
         
           
           
               
               
           
         
       
       wherein R 1  represents hydrogen, a halogen or a sulfono group SO 3 M, in which M is a metal ion, and R 2  represents hydrogen, or R 1  is Cl and R 2  is I, or a pharmaceutically acceptable salt thereof. 
     
     
         2 . A method of treating or preventing osteoporosis, comprising administering to a patient in need of treatment an effective amount of a compound according to Formula (I) 
       
         
           
           
               
               
           
         
       
       wherein R 1  represents hydrogen, a halogen or a sulfono group SO 3 M, in which M is a metal ion, and R 2  represents hydrogen, or R 1  is Cl and R 2  is I, or a pharmaceutically acceptable salt thereof. 
     
     
         3 . A method of treating or preventing or reducing the risk of low bone mineral density, bone loss, skeletal-related events including bone fractures, or increasing bone mass, comprising administering to a patient in need of treatment an effective amount of a compound according to Formula (I) 
       
         
           
           
               
               
           
         
       
       wherein R 1  represents hydrogen, a halogen or a sulfono group SO 3 M, in which M is a metal ion, and R 2  represents hydrogen, or R 1  is Cl and R 2  is I, or a pharmaceutically acceptable salt thereof. 
     
     
         4 . A method of treating or delaying the onset of localized bone loss associated with periodontal diseases or with periprosthetic osteolysis, comprising administering to a patient an effective amount of a compound according to Formula (I) 
       
         
           
           
               
               
           
         
       
       wherein R 1  represents hydrogen, a halogen or a sulfono group SO 3 M, in which M is a metal ion, and R 2  represents hydrogen, or R 1  is Cl and R 2  is I, or a pharmaceutically acceptable salt thereof. 
     
     
         5 . A method of treating or preventing Paget's disease, comprising administering to a patient in need of treatment an effective amount of a compound of Formula (I) 
       
         
           
           
               
               
           
         
       
       wherein R 1  represents hydrogen, a halogen or a sulfono group SO 3 M, in which M is a metal ion, and R 2  represents hydrogen, or R 1  is Cl and R 2  is I, or a pharmaceutically acceptable salt thereof. 
     
     
         6 . A method for preventing, or delaying the onset of, bone metastasis of cancer in a patient, comprising administering to the patient an effective amount of a compound of Formula (I) 
       
         
           
           
               
               
           
         
       
       wherein R 1  represents hydrogen, a halogen or a sulfono group SO 3 M, in which M is a metal ion, and R 2  represents hydrogen, or R 1  is Cl and R 2  is I, or a pharmaceutically acceptable salt thereof. 
     
     
         7 . A method of treating a cancer metastasized to bone, comprising administering to a patient having a cancer with bone metastasis an effective amount of a compound of Formula (I) 
       
         
           
           
               
               
           
         
       
       wherein R 1  represents hydrogen, a halogen or a sulfono group SO 3 M, in which M is a metal ion, and R 2  represents hydrogen, or R 1  is Cl and R 2  is I, or a pharmaceutically acceptable salt thereof.