Treatment of Comorbid Premature Ejaculation and Erectile Dysfunction

Abstract

The invention provides a method of treating comorbid premature ejaculation and erectile dysfunction. In particular, the method comprises administering an effective amount of a tramadol material and an effective amount of a phosphodiesterase inhibitor. The invention also provides a pharmaceutical composition comprising a pharmaceutically-acceptable carrier, a tramadol material and a phosphodiesterase inhibitor. The invention further provides a kit comprising a tramadol material and a phosphodiesterase inhibitor.

1 - 12 . (canceled) 
     
     
         13 . A kit comprising:
 (a) a container holding a tramadol material and a phosphodiesterase (PDE) inhibitor; or   (b) a first container holding a tramadol material and a second container holding a phosphodiesterase (PDE) inhibitor.   
     
     
         14 . The kit of  claim 13  wherein the tramadol material is tramadol or a pharmaceutically-acceptable form thereof, and the PDE inhibitor is a PDE3, PDE4 or PDE5 inhibitor. 
     
     
         15 . The kit of  claim 14  wherein the PDE inhibitor is a PDE5 inhibitor. 
     
     
         16 . The kit of  claim 15  wherein the tramadol material is (±)cis-tramadol or a pharmaceutically-acceptable salt thereof, and the PDE5 inhibitor is sildenafil or a pharmaceutically-acceptable form thereof, vardenafil or a pharmaceutically-acceptable form thereof, tadalafil or a pharmaceutically-acceptable form thereof, or a combination of two or more of the foregoing PDE5 inhibitors. 
     
     
         17 . The kit of  claim 16  wherein the tramadol material is (±)cis-tramadol hydrochloride, and the PDE5 inhibitor is sildenafil citrate, vardenafil hydrochloride, tadalafil or a combination of two or more of the foregoing PDE5 inhibitors. 
     
     
         18 . The kit of  claim 17  wherein the PDE5 inhibitor is sildenafil citrate. 
     
     
         19 . The kit of  claim 13  further comprising instructions for using the tramadol material and the PDE inhibitor to treat comorbid premature ejaculation and erectile dysfunction in a male.