Composition comprising (-)-delta9-trans-tetrahydrocannabinol

Abstract

A composition comprising a tetrahydrocannabinol compound, a solvent and an acid, wherein the tetrahydrocannabinol compound may be Δ 8 tetrahydrocannabinol, (−)-Δ 9 -trans-tetrahydrocannabinol or a side chain alkyl derivative of either compound, the solvent may be an oil or C 1 -C 4 alcohol (e.g. sesame oil or ethanol), and the acid may be an organic acid or a mineral acid.

1 . A composition comprising:
 (a) (−)-Δ 9 -trans-tetrahydrocannabinol,   (b) a solvent comprising sesame oil, and   (c) an acid selected from the group consisting of acetic acid, lactic acid, oxalic acid, succinic acid, salicylic acid and tartaric acid, and   
       wherein after up to 4 weeks at (i) 5° C., (ii) 25° C./60% relative humidity, or (iii) 40° C./75% relative humidity, the composition comprises: 
       a′) ≦3.69% cannabinol when the acid is acetic acid; 
       b′) ≦0.60% cannabinol when the acid is lactic acid; 
       c′) ≦0.12% cannabinol when the acid is oxalic acid; 
       d′) ≦0.1% cannabinol when the acid is succinic acid; 
       e′) ≦4.5% cannabinol when the acid is salicylic acid; or 
       f′) ≦0.12% cannabinol when the acid is tartaric acid. 
     
     
         2 . A composition comprising:
 (a) (−)-Δ 9 -trans-tetrahydrocannabinol,   (b) a solvent comprising sesame oil, and   (c) phosphoric acid, and   
       wherein the composition comprises ≦1.08% cannabinol after up to 16 days at (i) 25° C./60% relative humidity, or (ii) 40° C./75% relative humidity. 
     
     
         3 . A composition consisting essentially of:
 a) (−)-Δ 9 -trans-tetrahydrocannabinol,   b) a solvent comprising sesame oil, and   c) an acid selected from the group consisting of ascorbic acid, malic acid and fumaric acid,   
       and, optionally, one or more anti-oxidants, antimicrobial agents, preservatives or a combination thereof, and 
       wherein after up to 4 weeks at (i) 5° C., (ii) 25° C./60% relative humidity, or (iii) 40° C./75% relative humidity, the composition comprises: 
       a′) ≦0.05% cannabinol when the acid is ascorbic acid; 
       b′) ≦1.41% cannabinol when the acid is fumaric acid; or 
       c′) ≦0.18% cannabinol when the acid is malic acid. 
     
     
         4 . A composition comprising:
 (a) a tetrahydrocannabinol compound selected from Δ 8  tetrahydrocannabinol, (−)-Δ 9 -trans-tetrahydrocannabinol and side chain alkyl derivatives of either compound,   (b) a solvent comprising C 1 -C 4  alcohols, and   (c) an acid selected from the group consisting of ascorbic acid, malic acid and fumaric acid.   
     
     
         5 . A composition comprising:
 (a) a tetrahydrocannabinol compound selected from Δ 8  tetrahydrocannabinol, (−)-Δ 9 -trans-tetrahydrocannabinol and side chain alkyl derivatives of either compound,   (b) a solvent comprising ethanol, and   (c) carbonic acid formed from dissolved CO 2  in the ethanol.   
     
     
         6 . A composition consisting essentially of:
 a) a tetrahydrocannabinol compound selected from Δ 8 -tetrahydrocannabinol, (−)-Δ 9 -trans-tetrahydrocannabinol and side chain alkyl derivatives of either compound,   b) a solvent comprising ethanol, and   c) carbonic acid formed from dissolved CO 2  in the ethanol,   and, optionally, one or more anti-oxidants, antimicrobial agents, preservatives or a combination thereof.