US2012009198A1PendingUtilityA1

Compositions and Methods for Modulating Immune Response

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Assignee: CHEN DAVID C PPriority: Jul 7, 2010Filed: Jul 7, 2010Published: Jan 12, 2012
Est. expiryJul 7, 2030(~3.9 yrs left)· nominal 20-yr term from priority
Inventors:David C. P. ChenYi-Shu Chung
A61K 35/57A61K 2039/505A61P 37/00C07K 2317/76C07K 16/121C07K 2317/11
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PatentIndex Score
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Claims

Abstract

The present invention relates to a method for modulating immune response in a subject, which comprises administering to the subject an effective amount of a composition comprising a yolk or yolk antibody obtained from an egg of a fowl which has been immunized using Helicobacter pylori as an antigen. In particular, the method of the invention is effective in enhancing production of IFN-γ and suppressing production of IL-4 and IL-5 in a subject. Also provided is a composition which comprises said yolk or yolk antibody in combination with polypore and chitosan.

Claims

exact text as granted — not AI-modified
1 . A method for modulating immune response in a subject comprising administering to the subject a composition comprising a yolk or yolk antibody obtained from an egg of a fowl which has been immunized using  Helicobacter pylori  as an antigen, wherein the composition is in an amount effective to enhance cytotoxicity activity of natural killer cells, enhance production of IFN-γ, or suppress production of IL-4 or IL-5 in the subject. 
     
     
         2 . The method of  claim 1 , wherein the fowl is selected from the group consisting of chickens, ducks and geese. 
     
     
         3 . The method of  claim 1 , wherein the fowl is a hen. 
     
     
         4 . The method of  claim 1 , wherein the composition is in the form of powder. 
     
     
         5 . The method of  claim 1 , wherein the composition is in an amount effective to enhance cytotoxicity activity of natural killer cells in the subject. 
     
     
         6 . The method of  claim 1 , wherein the composition is in an amount effective to enhance production of IFN-γ in the subject. 
     
     
         7 . The method of  claim 1 , wherein the composition is in an amount effective to suppress production of IL-4 in the subject. 
     
     
         8 . The method of  claim 1 , wherein the composition is in an amount effective to suppress production of IL-5 in the subject. 
     
     
         9 . The method of  claim 1 , wherein the composition is orally administered to the subject. 
     
     
         10 . (canceled) 
     
     
         11 . (canceled) 
     
     
         12 . (canceled)

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