US2012004170A1PendingUtilityA1

Formulation Comprising Bioactive Agents And Method Of Using Same

35
Individually held — no corporate assignee on recordPriority: Feb 8, 2002Filed: Jan 26, 2011Published: Jan 5, 2012
Est. expiryFeb 8, 2022(expired)· nominal 20-yr term from priority
Inventors:Susan J. SofiaDaniel K. SchwartzWolfgang Friess
A61P 25/00Y10T428/2982A61P 19/08A61P 1/02A61K 38/1875A61P 19/10A61K 9/1694A61K 9/1688A61P 17/02A61P 19/00
35
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Claims

Abstract

Disclosed are methods of making bioactive BMP-2 microparticles and methods of using the microparticles.

Claims

exact text as granted — not AI-modified
1 . A purified microparticle comprising a precipitated bioactive bone morphogenetic protein 2 (BMP-2). 
     
     
         2 . The microparticle of  claim 1 , wherein said BMP-2 has an amino acid sequence of a human BMP-2. 
     
     
         3 . The microparticle of  claim 1 , wherein said BMP-2 is a recombinantly expressed protein. 
     
     
         4 . The microparticle of  claim 2 , wherein said BMP-2 is a recombinantly expressed protein. 
     
     
         5 . The microparticle of  claim 1 , wherein said microparticle has a diameter from about 0.1 μm to about 2000 μm. 
     
     
         6 . The microparticle of  claim 1 , wherein said microparticle has a diameter from about 5 μm to about 750 μm. 
     
     
         7 . The microparticle of  claim 1 , wherein said microparticle has a diameter from about 15 μm to about 250 μm. 
     
     
         8 . The microparticle of  claim 1 , wherein said microparticle has a diameter from about 25 μm to about 50 μm. 
     
     
         9 . The microparticle of  claim 1 , wherein said microparticle is provided as a lyophilized formulation. 
     
     
         10 . The microparticle of  claim 1 , wherein said microparticle is provided as an aqueous formulation. 
     
     
         11 . The microparticle of  claim 1 , wherein said microparticle is provided in association with a polymeric carrier. 
     
     
         12 . The microparticle of  claim 11 , wherein said polymeric carrier is biodegradable. 
     
     
         13 . The microparticle of  claim 11 , wherein said polymeric carrier is a polylactide, polylactide-co-glycolide, polyanhydride, polyorthoester, polyethylenevinylacetate, or nylon. 
     
     
         14 . A pharmaceutical composition comprising a precipitated bioactive bone morphogenetic protein 2 (BMP-2) microparticle and a pharmaceutically acceptable carrier. 
     
     
         15 . The pharmaceutical composition of  claim 14 , further comprising resolubilized BMP-2 protein. 
     
     
         16 - 35 . (canceled)

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