Compositions and methods for inhibiting nf-kb mediated tumorigenicity and adhesion-dependent survival of cancer cells

Abstract

Disclosed are compositions and methods for inhibiting NF-κB mediated cellular proliferation and metastasis. This abstract is intended to be used as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

1 - 72 . (canceled) 
     
     
         73 . A method for inhibiting reseeding of cancer cells during or after surgical resection of a tumor: comprising administering to a subject a compound having a structure selected from: 
       
         
           
           
               
               
           
         
       
     
     
         74 . The method of  claim 73 , wherein the compound is administered prior to the resection. 
     
     
         75 . The method of  claim 73 , wherein the compound is administered after the resection. 
     
     
         76 . The method of  claim 73 , wherein the compound is administered within 10 days of the resection. 
     
     
         77 . The method of  claim 73 , wherein the compound is administered within 5 days of the resection. 
     
     
         78 . The method of  claim 73 , wherein the compound is: 
       
         
           
           
               
               
           
         
       
     
     
         79 . The method of  claim 73 , wherein the cancer cells are HT-29 colon cancer cells. 
     
     
         80 . A method for inhibiting reseeding of cancer cells during or after surgical resection of a tumor: comprising administering to a subject a compound having a structure: 
       
         
           
           
               
               
           
         
         wherein R is alkyl; and 
         wherein n is a positive integer, wherein valence is satisfied. 
       
     
     
         81 . The method of  claim 80 , wherein the compound is the E-isomer. 
     
     
         82 . The method of  claim 80 , wherein the compound is: 
       
         
           
           
               
               
           
         
       
     
     
         83 . The method of  claim 80 , wherein the compound is: 
       
         
           
           
               
               
           
         
       
     
     
         84 . The method of  claim 80 , wherein the compound is administered prior to the resection. 
     
     
         85 . The method of  claim 80 , wherein the compound is administered after the resection. 
     
     
         86 . The method of  claim 80 , wherein the compound is administered within 10 days of the resection. 
     
     
         87 . The method of  claim 80 , wherein the compound is administered within 5 days of the resection. 
     
     
         88 . The method of  claim 80 , wherein the cancer cells are HT-29 colon cancer cells. 
     
     
         89 . A method for treating cancer cells in a subject, comprising administering a NF-κB inhibitor to the subject, thereby causing an NF-κB inhibition. 
     
     
         90 . The method of  claim 89 , wherein the cancer cells are not myeloma cells. 
     
     
         91 . The method of  claim 89 , wherein the NF-κB inhibition promotes apoptosis of the cancer cells, inhibits readhesion of the cancer cells, and/or inhibits metastasis of the cancer cells. 
     
     
         92 . The method of  claim 89 , wherein the NF-κB inhibitor comprises a compound having a structure: 
       
         
           
           
               
               
           
         
         wherein R is alkyl; and 
         wherein n is a positive integer, wherein valence is satisfied.