Soft and Calcified Tissue Implants

Abstract

Disclosed herein is processed dermis graft for use in orthopedic surgical procedures. Specifically exemplified herein is a processed dermis graft comprising one or more bone blacks having a groove cut into the surface thereof, wherein said groove is sufficient to accommodate a fixation screw. Also disclosed is a method of processing dermis that results in a dermis derived implant suitable to replace a tendon or ligament in a recipient in need thereof. Other compositions and applications of a dermis derived implant, and methods of manufacture and use, are disclosed.

1 - 74 . (canceled) 
     
     
         75 . An implant comprising:
 a) a section of processed soft tissue comprising a first end and a second end;   b) a first bone block attached by pinning to the first end of the processed soft tissue; and   c) a second bone block attached to the second end of the soft tissue;   wherein the first bone block is obtained from a xenogenic source, and the processed soft tissue is obtained from an allogenic source;   wherein each of the bone blocks comprises cortical bone, cancellous bone, or both; and   wherein each of the bone blocks comprises bone that is mineralized, partially demineralized, or fully demineralized.   
     
     
         76 . The implant of  claim 75 , wherein the processed soft tissue is selected from the group consisting of ligament, tendon, muscle, dura, pericardium, fascia, and peritoneum. 
     
     
         77 . The implant of  claim 75 , wherein the first bone block is pre-shaped into a dowel. 
     
     
         78 . The implant of  claim 77 , wherein at least one of the bone blocks further comprises a groove thereon. 
     
     
         79 . The implant of  claim 75 , wherein the first bone block attached to the first end of the processed soft tissue is a different shape than the second bone block attached to the second end of the processed soft tissue. 
     
     
         80 . The implant of  claim 75 , wherein the bone blocks are pre-shaped into dowels having tapered ends. 
     
     
         81 . The implant of  claim 75 , wherein the first bone block comprises a proximal region and a distal region in relation to the processed soft tissue, the proximal region being tapered; and
 wherein the second bone block comprises a proximal region and a distal region in relation to the processed soft tissue, the distal region being tapered.   
     
     
         82 . The implant of  claim 81 , wherein at least one of the bone blocks further comprises a groove thereon. 
     
     
         83 . An implant comprising:
 a) a section of processed soft tissue comprising a first end and a second end; and   b) a first bone block attached by pinning to at least one of the first end or the second end of the processed soft tissue,   wherein the bone block is obtained from an xenogenic source, and the processed soft tissue is obtained from an allogenic source.   
     
     
         84 . The implant of  claim 83 , wherein the first bone block is attached to the first end of the soft tissue and a second bone block is attached to the second end of the soft tissue, and wherein each of the bone blocks comprises cortical bone, cancellous bone, or both. 
     
     
         85 . The implant of  claim 83 , wherein the first bone block comprises bone that is mineralized, partially demineralized, or fully demineralized. 
     
     
         86 . The implant of  claim 83 , wherein the processed soft tissue is selected from the group consisting of ligament, tendon, muscle, dura, pericardium, fascia, and peritoneum. 
     
     
         87 . The implant of  claim 83 , wherein the first bone block is pre-shaped into a dowel. 
     
     
         88 . The implant of  claim 87 , wherein the first bone block further comprises a groove thereon. 
     
     
         89 . The implant of  claim 83 , wherein the first bone block is attached to the first end of the processed soft tissue and a second bone block is attached to the second end of the processed soft tissue, and wherein the first bone block of the first end of the processed soft tissue is a different size than the second bone block attached to the second end of the processed soft tissue. 
     
     
         90 . The implant of  claim 83 , wherein the first bone block is attached to the first end of the soft tissue and a second bone block is attached to the second end of the soft tissue, and wherein the bone blocks are pre-shaped into dowels. 
     
     
         91 . The implant of  claim 90 , wherein the bone blocks are pre-shaped into dowels having tapered ends. 
     
     
         92 . The implant of  claim 83 , wherein the first bone block is attached to the first end of the processed soft tissue and a second bone block is attached to the second end of the processed soft tissue; wherein the first bone block comprises a proximal region and a distal region in relation to the processed soft tissue, the proximal region being tapered; and wherein the second bone block comprises a proximal region and a distal region in relation to the processed soft tissue, the distal region being tapered. 
     
     
         93 . The implant of  claim 92 , wherein at least one of the bone blocks further comprises a groove thereon. 
     
     
         94 . The implant of  claim 84 , wherein the second bone block is attached to the processed soft tissue via a naturally occurring attachment. 
     
     
         95 . The implant of  claim 75 , wherein the second bone block is attached to the processed soft tissue via a naturally occurring attachment. 
     
     
         96 . The implant of either of  claim 75  or  84 , wherein the first and second bone blocks are made from substantially the same material. 
     
     
         97 . The implant of either of  claim 75  or  84 , wherein the first and second bone blocks are made from substantially different material. 
     
     
         98 . The implant of either of  claim 76  or  86 , wherein the processed soft tissue comprises ligament or tendon. 
     
     
         99 . The implant of  claim 96 , wherein the first and second bone blocks comprise cortical bone. 
     
     
         100 . The implant of  claim 96 , wherein the first and second bone blocks comprise cancellous bone. 
     
     
         101 . The implant of  claim 96 , wherein the first and second bone blocks comprise both cortical and cancellous bone. 
     
     
         102 . The implant of  claim 97 , wherein one of the first or second bone blocks comprises cortical bone. 
     
     
         103 . The implant of  claim 97 , wherein one of the first or second bone blocks comprises cancellous bone. 
     
     
         104 . The implant of  claim 97 , wherein one of the first or second bone blocks comprises both cortical and cancellous bone.