Remedy for Chronic Inflammation and Antibody to be Used Therein

Abstract

The invention provides a remedy for chronic inflammation and an anti-TNIIIA2 antibody to be used therein. The remedy includes an antibody recognizing TNIIIA2, that is a peptide derived from a partial sequence A2 of a human tenascin-C fibronectin III-like repetitive sequence and having the amino acid sequence RSTDLPGLKAATHYTITIRGVC (SEQ ID NO: 1).

1 . An antibody recognizing a peptide derived from a partial sequence A2 of a human Tenascin-C fibronectin III-like repetitive sequence. 
     
     
         2 . The antibody of  claim 1  that recognizes a peptide having the amino acid sequence of SEQ ID NO: 2. 
     
     
         3 . An immune cell infiltration inhibitor comprising the antibody of  claim 1 . 
     
     
         4 . A cell death inducer for inflammatory cells, the cell death inducer comprising the antibody of  claim 1 . 
     
     
         5 . A chronic inflammation remedy comprising the antibody of  claim 1 . 
     
     
         6 . The antibody of  claim 1  that recognizes a peptide having the amino acid sequence of SEQ ID NO: 1. 
     
     
         7 . The antibody of  claim 1  that recognizes an antigen, the antigen being a fusion protein containing a hapten, the hapten having the amino acid sequence of SEQ ID NO: 3. 
     
     
         8 . An immune cell infiltration inhibitor comprising the antibody of  claim 2 . 
     
     
         9 . A cell death inducer for inflammatory cells, the cell death inducer comprising the antibody of  claim 2 . 
     
     
         10 . A chronic inflammation remedy comprising the antibody of  claim 2 . 
     
     
         11 . An immune cell infiltration inhibitor comprising the antibody of  claim 6 . 
     
     
         12 . A cell death inducer for inflammatory cells, the cell death inducer comprising the antibody of  claim 6 . 
     
     
         13 . A chronic inflammation remedy comprising the antibody of  claim 6 . 
     
     
         14 . An immune cell infiltration inhibitor comprising the antibody of  claim 7 . 
     
     
         15 . A cell death inducer for inflammatory cells, the cell death inducer comprising the antibody of  claim 7 . 
     
     
         16 . A chronic inflammation remedy comprising the antibody of  claim 7 .