Method for prongf assay for in vitro diagnosis of cancer in particular breast, thyroid or lung cancer and therapeutic use of prongf

Abstract

A ProNGF inhibitor for preparing a drug, said drug being in particular useful for blocking remote dissemination and cell invasion in patients suffering from cancer, in particular breast, thyroid or lung cancer.

1 . A method for treatment of a patient suffering from cancer, comprising administering a therapeutically effective amount of a ProNGF inhibitor to said patient. 
     
     
         2 . The method as claimed in  claim 1 , wherein the amount is effective for blocking cell migration or invasion in patients suffering from cancer. 
     
     
         3 . The method as claimed in  claim 1 , wherein the ProNGF inhibitor is an anti-ProNGF antibody or a ProNGF receptor analog in soluble form. 
     
     
         4 . The method as claimed in  claim 1 , wherein said ProNGF inhibitor is able to specifically penetrate into cells of interest. 
     
     
         5 . The method as claimed in  claim 1 , wherein the ProNGF inhibitor is an siRNA of a ProNGF receptor. 
     
     
         6 . A method of blocking cancerous cell migration, comprising administering an effective amount of a ProNGF inhibitor to a person, thereby blocking migration of cancer cells. 
     
     
         7 . A pharmaceutical composition, comprising, as an active ingredient, at least one ProNGF inhibitor in combination with a pharmaceutually acceptable excipient. 
     
     
         8 . A pharmaceutical composition as claimed in  claim 7 , wherein the ProNGF inhibitor is an anti-ProNGF antibody or a ProNGF receptor analog in soluable form. 
     
     
         9 . A pharmaceutical composition as claimed in  claim 7 , wherein the ProNGF inhibitor is an siRNA of a ProNGF receptor. 
     
     
         10 . A pharmaceutical composition as claimed in  claim 7 , wherein said ProNGF inhibitor is able to specifically penetrate into cells of interest.