Medicament for the Treatment of Pain and Inflammation

Abstract

The use of vitamin D3 for the manufacture of a medicament for the transdermal treatment of neurogenic inflammation and neuropathic pain (including peripheral neuropathic pain); also a method for the relief of neurogenic inflammation and neuropathic pain using this medicament.

1 . A composition for the treatment of at least one selected from the group consisting of neurogenic inflammation, and neuropathic pain, and combinations thereof, wherein the composition comprises calciol (cholecalciferol) and wherein the composition is formulated for transdermal application. 
     
     
         2 . The composition as claimed in  claim 1 , wherein the composition further comprises a carrier medium suitable for transdermal application, in which calciol (cholecalciferol) is dispersed or dissolved. 
     
     
         3 . The composition as claimed in  claim 2 , wherein the carrier medium is selected from the group consisting of: aqueous-based cream, massaging oil, gel base, ointment, patches, impregnated sheet material, pessaries and suppositories. 
     
     
         4 . The composition as claimed in  claim 1 , wherein the calciol (cholecalciferol) is present in a concentration in the range of 5000 IU/gram to 100,000 IU/gram. 
     
     
         5 . The composition as claimed in  claim 4 , wherein the calciol (cholecalciferol) is present in a concentration of 40,000 IU/gram. 
     
     
         6 . The composition as claimed in  claim 1 , wherein the calciol (cholecalciferol) is in the form of a powder. 
     
     
         7 . The composition as claimed in  claim 1 , wherein the calciol (cholecalciferol) is dissolved in a plant oil. 
     
     
         8 . A method for relieving at least one selected from the group consisting of neurogenic inflammation, neuropathic pain, and combinations thereof, said method comprising the step of transdermally administering a composition comprising calciol (cholecalciferol) to a subject in need thereof. 
     
     
         9 . The method as claimed in  claim 8 , wherein the composition further comprises a carrier medium suitable for transdermal application, in which calciol (cholecalciferol) is dispersed or dissolved. 
     
     
         10 . The method as claimed in  claim 9 , wherein the carrier medium is selected from the group consisting of: aqueous-based cream, massaging oil, gel base, ointment, patches, impregnated sheet material, pessaries and suppositories. 
     
     
         11 . The method as claimed in  claim 8 , wherein the calciol (cholecalciferol) is present in a concentration in the range of 5000 IU/gram to 100,000 IU/gram. 
     
     
         12 . The composition as claimed in  claim 2 , wherein the carrier medium is selected from the group consisting of aqueous-based cream, massaging oil, gel base, ointment, patches, impregnated sheet material, pessaries, suppositories, aerosol sprays, non-aerosol sprays and combinations thereof. 
     
     
         13 . The composition as claimed in  claim 1 , wherein the calciol (cholecalciferol) is present in a concentration in the range of 5000 IU/gram to 200,000 IU/gram. 
     
     
         14 . The method as claimed in  claim 9 , wherein the carrier medium is selected from the group consisting of aqueous-based cream, massaging oil, gel base, ointment, patches, impregnated sheet material, pessaries, suppositories, aerosol sprays, non-aerosol sprays and combinations thereof. 
     
     
         15 . The method as claimed in  claim 8 , wherein the calciol (cholecalciferol) is present in a concentration in the range of 5000 IU/gram to 200,000 IU/gram.