Human e3alpha ubiquitin ligase family

Abstract

The present invention relates to a novel polypeptide encoding a protein which is the full length human ortholog of E3α ubiquitin ligase. The invention also relates to vector, host cells, antibodies and recombinant methods for producing the polypeptide. In addition, the invention discloses therapeutic, diagnostic and research utilities for these and related products.

1 - 50 . (canceled) 
     
     
         51 . A method for treating, preventing or ameliorating a medical condition in a mammal resulting from decreased levels of huE3α polypeptide comprising administering a huE3α polypeptide to said mammal. 
     
     
         52 . The method of  claim 51  wherein the huE3α polypeptide administered is the amino acid sequence set forth in SEQ ID NO: 2 or a fragment thereof at least 25 amino acids or a homolog, analog or variant of said huE3α polypeptide or fragment thereof. 
     
     
         53 . The method of  claim 51  wherein the huE3α polypeptide administered has the amino acid set forth in SEQ ID NO: 2 with at least one amino acid substitution. 
     
     
         54 . The method of  claim 51  wherein the huE3α polypeptide administered has the amino acid sequence set forth in SEQ ID NO: 2 with at least one amino acid deleted. 
     
     
         55 - 66 . (canceled)