US2011269710A1PendingUtilityA1

Pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same

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Individually held — no corporate assignee on recordPriority: Feb 1, 1999Filed: Jul 14, 2011Published: Nov 3, 2011
Est. expiryFeb 1, 2019(expired)· nominal 20-yr term from priority
Inventors:Harold G. BrownCarol A. CooperKristina J. HennessyKaren K. Brown
A61K 31/737A61K 31/726A61K 31/715A61P 35/04A23L 33/10A61K 31/727A23K 20/163A61K 47/44A61K 31/728A61K 9/0014A61K 31/736A61P 35/00Y02A50/30
56
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Claims

Abstract

The invention discloses the discovery that a pharmaceutical composition containing complex carbohydrates with or without natural or synthetic essential oils can work effectively as a topical, oral or mucosal pharmaceutical composition. Such pharmaceutical compositions reduce inflammation, assist in wound healing, protect against bruising, relieve itching, relieve pain and swelling and treat topical bacterial infections such as acne and decubitus ulcers and prevent and treat numerous other conditions and diseases. Such pharmaceutical compositions can be administered to mammals including humans. Also included in this invention are methods to deliver topically applied macromolecules into the tissue of mammals and methods of blocking the adhesion, metastatic and coronary cascades.

Claims

exact text as granted — not AI-modified
1 . A method for inhibiting tumor formation and tumor metastasis which comprises administering to a subject in need of inhibiting tumor formation and tumor metastasis a pharmacologically effective amount of at least one low purity complex carbohydrate selected from the group consisting of oligosaccharides, sialylated oligosacharides, polysaccharides and glycosaminoglycans. 
     
     
         2 . A method for preventing or treating tumor development and metastasis which comprises orally or mucosally administering to a mammal in need thereof for preventing or treating tumor development and metastasis a composition which comprises as an active ingredient a pharmacologically effective amount of at least one low purity complex carbohydrate selected from the group consisting of oligosaccharides, sialylated oligosaccharides, polysaccharides and glycosaminoglycans. 
     
     
         3 . A method for preventing or treating tumor development and metastasis which comprises orally administering to a mammal in need thereof for preventing or treating tumor development and metastasis a composition which comprises as an active ingredient 0.005 to 50 mg/kg body weight of at least one complex carbohydrate selected from the group consisting of oligosaccharides, sialylated oligosaccharides, polysaccharides, and glycosaminoglycans optionally with 0.0001 to 20% by vol. Essential oil. 
     
     
         4 . A method for preventing or treating tumor development and metastasis which comprises mucosally administering to a mammal in need thereof for preventing or treating tumor development and metastasis a composition which comprises as an active ingredient 0.005 to 50 mg/kg body weight of at least one complex carbohydrate selected from the group consisting of oligosaccharides, sialylated oligosaccharides, polysaccharides, and glycosaminoglycans optionally with 0.0001 to 20% by vol. Essential oil. 
     
     
         5 . The method of  claim 3 , wherein the tumor development and metastasis result from inflammation. 
     
     
         6 . The method of  claim 3  wherein the tumor development or metastasis are selected from the group consisting of sunburn, gastritic, ulcers and colitis. 
     
     
         7 . The method according to  claim 1 , wherein said complex carbohydrate is a polysaccharide. 
     
     
         8 . The method according to  claim 1 , wherein said complex carbohydrate is an oligosaccharide. 
     
     
         9 . The method according to  claim 3 , wherein said essential oil is natural or synthetic. 
     
     
         10 . The method according to  claim 9 , wherein said natural or synthetic essential oils are selected from the group consisting of Eucalyptus Oil, Rosemary Oil, Pine Needle Oil, Tea Tree Oil, Wintergreen Oil, Peppermint Oil, Spearmint Oil, Sweet Birch Oil, Camphor Oil, Sage Oil, Jojoba Oil, Cinnamon Oil, Anise Oil, Lemon Oil, Lime Oil, Orange Oil, Clove Oil Almond Oil, White Pine Oil Cardamon Oil, Cedar Leaf oil, Sweet Birch and EMU Oil. 
     
     
         11 . The method according to  claim 7 , wherein said polysaccharides are selected from the group consisting of a glycosaminoglycan and a mannan. 
     
     
         12 . The method according to  claim 11 , wherein said glycosaminoglycan is selected from the group consisting of hyaluronic acid, heparin, heparin sulfate, low molecular weight heparin, dermatan sulfate, chondroitin sulfate, polysulfated glycosaminoglycan, keratan sulfate, salts thereof and derivatives thereof. 
     
     
         13 . The method according to  claim 7 , wherein said polysaccharide is obtained from an extract of the Aloe Vera plant. 
     
     
         14 . The method according to  claim 8 , wherein said oligosaccharide is a sialylated sugar. 
     
     
         15 . The method according to  claim 9 , wherein said essential oil is an aromatic oil. 
     
     
         16 . The method according to  claim 1 , wherein said complex carbohydrates comprise a mixture of molecular weight ranges. 
     
     
         17 . The method according to  claim 16 , wherein said complex carbohydrates comprise a mixture of a high molecular weight complex carbohydrate and a low molecular weight complex carbohydrate. 
     
     
         18 . The method according to  claim 16 , wherein the high molecular weight and low molecular weight complex carbohydrate differ by molecular weight and chemical structure. 
     
     
         19 . The method according to  claim 16 , wherein said high molecular weight and low molecular weight complex carbohydrates range from two different size polymers of the same complex carbohydrates. 
     
     
         20 . The method according to  claim 1 , wherein said complex carbohydrates are in a concentration ranging from 0.1% to 99% wt/vol. 
     
     
         21 . The method according to  claim 1 , wherein said complex carbohydrates are in a concentration ranging from 0.5% to 3.0% wt/vol. 
     
     
         22 . The method according to  claim 1 , wherein said complex carbohydrates are in a concentration ranging from 0.01% to 5.0% wt/vol in an Aloe Vera gel concentrate base with a concentration of between 50% and 99% vol/vol. 
     
     
         23 . The method according to  claim 1 , wherein said complex carbohydrates are in a concentration ranging from 0.01% to 5.0% wt/vol. 
     
     
         24 . The method according to  claim 1 , wherein said at least one complex carbohydrate has a molecular weight in the range of from 1,000 to less than 50,000 daltons. 
     
     
         25 . The method according to  claim 1 , wherein said at least one complex carbohydrate has a molecular weight in the range of from 100,000 to 300,000 daltons. 
     
     
         26 . The method according to  claim 1 , wherein said at least one complex carbohydrate has a molecular weight in the range of greater than 1,000,000 daltons. 
     
     
         27 . The method of  claim 1 , wherein the low purity complex carbohydrate contains up to 5% by weight contaminants. 
     
     
         28 . The method of  claim 1 , wherein the low purity complex carbohydrate contains less than 98% by weight hyaluronic acid. 
     
     
         29 . The method of  claim 1 , wherein the active ingredient is present in an amount of at least 0.01% wt/vol. 
     
     
         30 . The method of  claim 1 , wherein the active ingredient is present in an amount of at least 1% wt/vol. 
     
     
         31 . The method of  claim 1 , wherein said at least one low or cosmetic or food grade complex carbohydrate has a molecular weight in the range of from 1,000 to less than 50,000, from 100,000 to 500,000, or greater than 1,000,000 daltons. 
     
     
         32 . The method according to  claim 1 , wherein the complex carbohydrate is a hyaluronic acid or salt or derivative thereof.

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