Natural Vitamin E Compositions with Superior Antioxidant Potency

Abstract

Compositions for increased antioxidant potency of natural vitamin E (d-alpha-tocopherol), comprising alpha-, beta-, delta-, and gamma-forms of tocopherols and tocotrienols are disclosed. All of these compositions provide 400 International Units (IU), based on one mg of d-alpha-tocopherol provides 1.49 IU. These compositions showed antioxidant activities superior to natural d-alpha-tocopherol. These compositions are designed to provide protection of the cell membrane lipid layer, and protection against heart disease, cancer, and eye disease.

1 . A composition comprising:
 (a) d-alpha-tocopherol;   (b) mixed tocopherols comprising alpha-tocopherol, beta-tocopherol, delta-tocopherol, gamma-tocopherol or mixtures thereof; and   (c) tocotrienols.   
     
     
         2 . The composition of  claim 1 , wherein said mixed tocopherols comprise 70% tocopherols in the amounts of 5 to 15% alpha-tocopherol, 1 to 3% beta-tocopherols, 30 to 50% gamma-tocopherol, and 10 to 20% delta-tocopherol. 
     
     
         3 . The composition of  claim 1 , wherein said mixed tocopherols comprise 90% tocopherols in the amounts of 10 to 20% alpha-tocopherol, 2 to 4% beta-tocopherol, 50 to 80% gamma-tocopherol, and 10 to 20% delta-tocopherol. 
     
     
         4 . The composition of  claim 1 , wherein said tocotrienols are obtained from rice oil and said tocotrienols contain 10 to 15% alpha-tocopherol, 10 to 12% alpha-tocotrienol, 10 to 12% gamma-tocotrienol, and 2 to 10% other tocopherols and tocotrienols. 
     
     
         5 . The composition of  claim 1 , wherein said tocotrienols are obtained from palm oil and said tocotrienols contain 8 to 14% alpha-tocopherol, 8 to 14% alpha-tocotrienol, 15 to 30% gamma-tocotrienol, and 5 to 10% delta-tocotrienol. 
     
     
         6 - 10 . (canceled) 
     
     
         11 . A method to treat or prevent eye disease comprising the step of providing to a subject in need thereof, a composition comprising d-alpha-tocopherol, mixed tocopherols comprising alpha-tocopherol, beta-tocopherol, delta-tocopherol, gamma-tocopherol or mixtures thereof; and tocotrienols. 
     
     
         12 . The method of  claim 11 , wherein said mixed tocopherols comprise 70% tocopherols in the amounts of 5 to 15% alpha-tocopherol, 1 to 3% beta-tocopherols, 30 to 50% gamma-tocopherol, and 10 to 20% delta-tocopherol. 
     
     
         13 . The method of  claim 11 , wherein said mixed tocopherols comprise 90% tocopherols in the amounts of 10 to 20% alpha-tocopherol, 2 to 4% beta-tocopherol, 50 to 80 gamma-tocopherol, and 10 to 20% delta-tocopherol. 
     
     
         14 . The method of  claim 11 , wherein said tocotrienols are obtained from rice oil and said tocotrienols contain 10 to 15% alpha-tocopherol, 10 to 12% alpha-tocotrienol, 10 to 12% gamma-tocotrienol, and 2 to 10% other tocopherols and tocotrienols. 
     
     
         15 . The method of  claim 11 , wherein said tocotrienols are obtained from palm oil and said tocotrienols contain 8 to 14% alpha-tocopherol, 8 to 14% alpha-tocotrienol, 15 to 30% gamma-tocotrienol, and 5 to 10% delta-tocotrienol.