US2011245592A1PendingUtilityA1

Secretome Profile-Facilitated In Vitro Fertilization

41
Individually held — no corporate assignee on recordPriority: Apr 6, 2010Filed: Apr 6, 2011Published: Oct 6, 2011
Est. expiryApr 6, 2030(~3.7 yrs left)· nominal 20-yr term from priority
Inventors:William B. SchoolcraftMandy Katz-JaffeSusanna Mcreynolds
G01N 33/689G01N 2800/52G01N 33/543
41
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Claims

Abstract

Secretome profiling improves the pregnancy success rate of in vitro fertilization processes, while reducing the risk of multiple births.

Claims

exact text as granted — not AI-modified
1 . A system for enhancing the pregnancy success rate of in vitro fertilization, comprising:
 means for determining the secretome profile of an embryo to identify proteins implicated in implantation success; and   means for recommending whether to implant the embryo on the basis of the secretome profile.   
     
     
         2 . The system of  claim 1 , further comprising data representative of a secretome profile of an embryo acquired by ELISA. 
     
     
         3 . The system of  claim 2 , further comprising the secretome profile of an embryo acquired using a secretome panel selected from the group consisting of SEQ ID Nos. 1-403. 
     
     
         4 . The system of  claim 3 , further comprising the secretome profile of an embryo acquired using a secretome panel selected as one or more members of the group consisting of SEQ ID Nos. 1-404. 
     
     
         5 . The system of  claim 3 , further comprising the secretome profile of an embryo acquired using a secretome panel selected as one or more members of the group consisting of SEQ ID Nos. 261-404. 
     
     
         6 . The system of  claim 3 , further comprising the secretome profile of an embryo acquired using a secretome panel selected as one or more members of the group consisting of SEQ ID Nos. 310, 311, 313, 317, 318, 319, 334, 335, 336, 337, 338, 339, 340, 341, 342, 343, 345, 346, 347, 348, 349, 350, 368, 371, 374, 383, 391, 397, 398, 399, 402, 403, and 404. 
     
     
         7 . The system of  claim 3 , further comprising the secretome profile of an embryo acquired using a secretome panel selected as one or more members of the group consisting of SEQ ID Nos. 310, 311, 313, 318, 319, 334, 335, 336, 337, 338, 339, 340, 341, 342, 343, 345, 346, 347, 348, 349, 350, 368, 371, 374, 391, 397, 398, 399, 402, 403, and 404. 
     
     
         8 . The system of  claim 3 , further comprising the secretome profile of an embryo acquired using a secretome panel selected as one or more members of the group consisting of SEQ ID Nos. 317 and 383. 
     
     
         9 . The system of  claim 1 , further comprising the secretome profile of an embryo acquired using a secretome panel selected as one or more members of the group consisting of SEQ ID Nos. 1-404. 
     
     
         10 . The system of  claim 1 , further comprising the secretome profile of an embryo acquired using a secretome panel selected as one or more members of the group consisting of SEQ ID Nos. 261-404. 
     
     
         11 . The system of  claim 1 , further comprising the secretome profile of an embryo acquired using a secretome panel selected as one or more members of the group consisting of SEQ ID Nos. 310, 311, 313, 317, 318, 319, 334, 335, 336, 337, 338, 339, 340, 341, 342, 343, 345, 346, 347, 348, 349, 350, 368, 371, 374, 383, 391, 397, 398, 399, 402, 403, and 404. 
     
     
         12 . The system of  claim 1 , further comprising the secretome profile of an embryo acquired using a secretome panel selected as one or more members of the group consisting of SEQ ID Nos. 310, 311, 313, 318, 319, 334, 335, 336, 337, 338, 339, 340, 341, 342, 343, 345, 346, 347, 348, 349, 350, 368, 371, 374, 391, 397, 398, 399, 402, 403, and 404. 
     
     
         13 . The system of  claim 1 , further comprising the secretome profile of an embryo acquired using a secretome panel selected as one or more members of the group consisting of SEQ ID Nos. 317 and 383. 
     
     
         14 . A method of in vitro fertilization, comprising:
 determining the secretome profile of a candidate embryo to ascertain proteins implicated in implantation success;   modeling on basis of the secretome profile to assess candidate embryo viability for   recommending whether to implant the candidate embryo on the basis of the viability assessment; and   conditionally implanting the candidate embryo on the basis of the recommendation.   
     
     
         15 . The method of  claim 14 , wherein the step of determining the secretome profile includes using a secretome panel selected as one or more members of the group consisting of SEQ ID Nos. 1-404. 
     
     
         16 . The method of  claim 14 , wherein the step of determining the secretome profile includes using a secretome panel selected as one or more members of the group consisting of SEQ ID Nos. 261-404. 
     
     
         17 . The method of  claim 14 , wherein the step of determining the secretome profile includes using a secretome panel selected as one or more members of the group consisting of SEQ ID Nos. 310, 311, 313, 317, 318, 319, 334, 335, 336, 337, 338, 339, 340, 341, 342, 343, 345, 346, 347, 348, 349, 350, 368, 371, 374, 383, 391, 397, 398, 399, 402, 403, and 404. 
     
     
         18 . The method of  claim 14 , wherein the step of determining the secretome profile includes using a secretome panel selected as one or more members of the group consisting of SEQ ID Nos. 310, 311, 313, 318, 319, 334, 335, 336, 337, 338, 339, 340, 341, 342, 343, 345, 346, 347, 348, 349, 350, 368, 371, 374, 391, 397, 398, 399, 402, 403, and 404. 
     
     
         19 . The method of  claim 14 , wherein the step of determining the secretome profile includes using a secretome panel selected as one or more members of the group consisting of SEQ ID Nos. 317 and 383. 
     
     
         20 . In an ELISA assay kit comprising a plurality of microwells for the quantitation of protein content in a sample, the improvement comprising:
 the microwells being constructed and arranged to quantitate for a plurality of proteins selected from SEQ ID Nos. 1-404.   
     
     
         21 . The kit  claim 20 , wherein the plurality of proteins are selected from the group consisting of SEQ ID Nos. 261-404. 
     
     
         22 . The kit  claim 20 , wherein the plurality of proteins are selected from the group consisting of SEQ ID Nos. 310, 311, 313, 317, 318, 319, 334, 335, 336, 337, 338, 339, 340, 341, 342, 343, 345, 346, 347, 348, 349, 350, 368, 371, 374, 383, 391, 397, 398, 399, 402, 403, and 404. 
     
     
         23 . The kit  claim 20 , wherein the plurality of proteins are selected from the group consisting of SEQ ID Nos. 310, 311, 313, 318, 319, 334, 335, 336, 337, 338, 339, 340, 341, 342, 343, 345, 346, 347, 348, 349, 350, 368, 371, 374, 391, 397, 398, 399, 402, 403, and 404. 
     
     
         24 . The kit  claim 20 , wherein the plurality of proteins are selected from the group consisting of SEQ ID Nos. 317 and 383.

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