Substituted Tetracycline Compounds as Synergistic Antifungal Agents

Abstract

The present invention relates to substituted tetracycline compounds and related methods for increasing the antifungal activity of an antifungal agent. The methods include administering to a subject an effective amount of a substituted tetracycline compound in combination with an antifungal agent such that the subject is treated for the fungal associated disorder.

1 . A compound selected from the group consisting of: 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         and pharmaceutically acceptable salts and enantiomers thereof. 
       
     
     
         2 . The compound of  claim 1 , wherein said compound is: 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt or enantiomer thereof. 
       
     
     
         3 . The compound of  claim 1 , wherein said compound is: 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt or enantiomer thereof. 
       
     
     
         4 . The compound of  claim 1 , wherein said compound is: 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt or enantiomer thereof. 
       
     
     
         5 . The compound of  claim 1 , wherein said compound is: 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt or enantiomer thereof. 
       
     
     
         6 . The compound of  claim 1 , wherein said compound is: 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt or enantiomer thereof. 
       
     
     
         7 . The compound of  claim 1 , wherein said compound is: 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt or enantiomer thereof. 
       
     
     
         8 . The compound of  claim 1 , wherein said compound is: 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt or enantiomer thereof. 
       
     
     
         9 . The compound of  claim 1 , wherein said compound is: 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt or enantiomer thereof. 
       
     
     
         10 . The compound of  claim 1 , wherein said compound is: 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt or enantiomer thereof. 
       
     
     
         11 . The compound of  claim 1 , wherein said compound is: 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt or enantiomer thereof. 
       
     
     
         12 . The compound of  claim 1 , wherein said compound is: 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt or enantiomer thereof. 
       
     
     
         13 . The compound of  claim 1 , wherein said compound is: 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt or enantiomer thereof. 
       
     
     
         14 . The compound of  claim 1 , wherein said compound is: 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt or enantiomer thereof. 
       
     
     
         15 . The compound of  claim 1 , wherein said compound is: 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt or enantiomer thereof. 
       
     
     
         16 . The compound of  claim 1 , wherein said compound is: 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt or enantiomer thereof. 
       
     
     
         17 . The compound of  claim 1 , wherein said compound is: 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt or enantiomer thereof. 
       
     
     
         18 . The compound of  claim 1 , wherein said compound is: 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt or enantiomer thereof. 
       
     
     
         19 . The compound of  claim 1 , wherein said compound is: 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt or enantiomer thereof. 
       
     
     
         20 . The compound of  claim 1 , wherein said compound is: 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt or enantiomer thereof.