US2011245286A1PendingUtilityA1

Treatment of inflammation using alpha 7 receptor-binding agonists

Assignee: THE FEINSTEIN INST MEDICAL RESPriority: Dec 6, 2002Filed: Feb 1, 2011Published: Oct 6, 2011
Est. expiryDec 6, 2022(expired)· nominal 20-yr term from priority
A61P 29/00A61K 31/439G01N 33/6863G01N 33/9406A61K 31/46A61P 1/18A61K 31/00G01N 2333/525A61K 31/444G01N 2333/54Y02A50/30
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Claims

Claims

exact text as granted — not AI-modified
1 - 55 . (canceled) 
     
     
         56 . A method of treating an inflammatory condition comprising administering to a patient in need thereof a cholinergic agonist selective for an α7 nicotinic receptor in an amount sufficient to decrease the amount of a proinflammatory cytokine that is released from a macrophage, wherein said inflammatory condition is selected from the group consisting of appendicitis, peptic, gastric or duodenal ulcers, ulcerative cholitis, peritonitis, pancreatitis, acute or ischemic colitis, diverticulitis, epiglottis, achalasia, cholangitis, cholecystitis, hepatitis, Crohn's disease, enteritis, Whipple's disease, asthma, allergy, anaphylactic shock, immune complex disease, organ ischemia, reperfusion injury, organ necrosis, hay fever, sepsis, septicemia, endotoxic shock, cachexia, hyperpyrexia, eosinophilic granuloma, granulomatosis, sarcoidosis, septic abortion, epididymitis, vaginitis, prostatitis, urethritis, bronchitis, emphysema, rhinitis, cystic fibrosis, pneumonitis, pneumoultramicroscopic silicovolcanoconiosis, alvealitis, bronchiolitis, pharyngitis, pleurisy, sinusitis, influenza, respiratory syncytial virus, herpes, HIV, hepatitis B, hepatitis C, disseminated bacteremia, Dengue fever, candidiasis, malaria, filariasis, amebiasis, hydatid cysts, burns, dermatitis, dermatomyositis, sunburn, urticaria, warts, wheals, vasulitis, angiitis, endocarditis, arteritis, artherosclerosis, thrombophlebitis, pericarditis, myocarditis, myocardial ischemia, periarteritis nodosa, rheumatic fever, Alzheimer's disease, coeliac disease, congestive heart failure, adult respiratory distress syndrome, chronic obstructive pulmonary disease, meningitis, encephalitis, multiple sclerosis, cerebral infarction, cerebral embolism, Guillame-Barre syndrome, neuritis, neuralgia, spinal cord injury, paralysis, uveitis, arthritides, arthralgias, osteomyelitis, fasciitis, Paget's disease, gout, periodontal disease, rheumatoid arthritis, synovitis, myasthenia gravis, thyroiditis, systemic lupus erythematosus, Goodpasture's syndrome, Behcet's syndrome, allograft rejection, graft-versus-host disease, Type I diabetes, Type II diabetes, ankylosing spondylitis, Berger's disease, Retier's syndrome, and Hodgkins disease. 
     
     
         57 . The method of  claim 56 , wherein the condition is selected from: hepatitis, hay fever, sarcoidosis, bronchitis, rhinitis, sinusitis, and atherosclerosis. 
     
     
         58 . A method of treating an inflammatory condition comprising administering to a patient in need thereof a cholinergic agonist selective for an α7 nicotinic receptor in an amount sufficient to decrease the inflammatory cytokine cascade. 
     
     
         59 . The method of  claim 58 , wherein said cascade causes either a systemic reaction or is mediated by a localized inflammatory cytokine cascade. 
     
     
         60 . A method of treating an inflammatory condition comprising administering to a patient in need thereof a cholinergic agonist selective for an α7 nicotinic receptor in an amount sufficient to decrease the amount of a proinflammatory cytokine that is released from a macrophage, wherein said inflammatory condition is a dermatological disease or condition of the skin.

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