Imaging diagnostics by combining contrast agents

Abstract

The present invention relates to the use of a combination of several contrast agents having different properties with respect to imaging representation.

1 . An extracellular contrast agent (ECCM) for the diagnosis of lesions in combination/conjunction with a lesion-specific contrast agent (LSCM). 
     
     
         2 . The extracellular contrast agent (ECCM) for the diagnosis of lesions according to  claim 1 , wherein the individual contrast agents of the combination of ECCM and LSCM are imaging contrast agents for a synthetic imaging method (monomodal) or multiple synthetic imaging methods (polymodal). 
     
     
         3 . The extracellular contrast agent (ECCM) for the diagnosis of lesions according to  claim 1  or  2 , wherein, in the case of the monomodal method, ECCM and LSCM are to be administered consecutively, wherein either the ECCM or the LSCM can be administered first. 
     
     
         4 . The extracellular contrast agent (ECCM) for the diagnosis of lesions according to  claim 1  or  2 , wherein, in the case of the polymodal method either
 a) the ECCM and the LSCM are to be administered consecutively; or 
 b) the ECCM and the LSCM are to be administered simultaneously. 
 
     
     
         5 . The extracellular contrast agent (ECCM) for the diagnosis of lesions in combination/conjunction with a lesion-specific contrast agent (LSCM) according to any one of  claims 1  to  4 , wherein the ECCM and the LSCM are to be administered with a time delay of at least 10 to 15 minutes. 
     
     
         6 . The extracellular contrast agent (ECCM) for the diagnosis of lesions in combination/conjunction with a lesion-specific contrast agent (LSCM) according to any one of  claims 1  to  5 , wherein the ECCM is gadolinium-DTPA. 
     
     
         7 . The extracellular contrast agent (ECCM) for the diagnosis of lesions in combination/conjunction with a lesion-specific contrast agent (LSCM) according to any one of  claims 1  to  6 , wherein the LSCM is enriched in the lesion after 10 minutes and is retained there for at least 1 hour. 
     
     
         8 . The extracellular contrast agent (ECCM) for the diagnosis of lesions in combination/conjunction with a lesion specific contrast agent (LSCM) according to any one of  claims 1  to  7 , wherein the imaging signals are immediately interpolated. 
     
     
         9 . An application device for the combined application of an extracellular contrast agent (ECCM) for the diagnosis of lesions in combination/conjunction with a lesion-specific contrast agent (LSCM), wherein said application device allows separate recording and application of the ECCM and the LSCM. 
     
     
         10 . The application device according to  claim 9 , wherein said application device has at least two chambers or receptacles for separate recording and application of the ECCM and the LSCM. 
     
     
         11 . A method for the diagnosis of lesions, wherein an extracellular contrast agent (ECCM) is administered in combination/conjunction with a lesion-specific contrast agent and, preferably, the interpolation of the imaging signals occurs immediately.