Antimicrobial flush solutions

Abstract

The present invention provides antimicrobial solutions that comprise at least one alcohol, at least one antimicrobial agent and at least one chelator and/or anticoagulant. Also provided are methods for rapidly reducing a microbe or a virus from surfaces including surfaces of indwelling medical devices and organic surfaces such as skin and sutures, and inorganic surfaces such as hospital equipment, pipelines etc.

1 . An antimicrobial solution comprising at least one alcohol, at least one antimicrobial agent other than chlorhexidine, and at least one chelator. 
     
     
         2 - 8 . (canceled) 
     
     
         9 . The solution of  claim 1 , wherein the antimicrobial agent is an antiseptic agent. 
     
     
         10 . The solution of  claim 9 , wherein the antiseptic agent is glutaraldehyde. 
     
     
         11 . The solution of  claim 1 , wherein the chelator is selected from the group of chelators consisting of EDTA free acid, EDTA 2Na, EDTA 3Na, EDTA 4Na, EDTA 2K, EDTA 2Li, EDTA 2NH 4 , EDTA 3K, Ba(II)-EDTA, Ca(II)-EDTA, Co(II)-EDTACu(II)-EDTA, Dy(III)-EDTA, Eu(III)-EDTA, Fe(III)-EDTA, In(III-EDTA, La(III)-EDTA, CyDTA, DHEG, diethylenetriamine penta acetic acid (DTPA), DTPA-OH, EDDA, EDDP, EDDPO, EDTA-OH, EDTPO, EGTA, HBED, HDTA, HIDA, IDA, Methyl-EDTA, NTA, NTP, NTPO, O-Bistren, TTHA, EGTA, DMSA, deferoxamine, dimercaprol, zinc citrate, a combination of bismuth and citrate, penicillamine, succimer and Etidronate. 
     
     
         12 . (canceled) 
     
     
         13 . The solution of  claim 1 , wherein the alcohol is ethanol, methanol, isopropanol, propylene glycol, benzyl alcohol, chlorobutanol or phenylethyl alcohol. 
     
     
         14 . The solution of  claim 1 , wherein the concentration of alcohol is in the range of 10%-80% (v/v). 
     
     
         15 . The solution of  claim 14 , wherein the concentration of the alcohol is in the range of 10-40%. 
     
     
         16 . The solution of  claim 15 , wherein the concentration of alcohol is in the range of 15-30%. 
     
     
         17 . The solution of  claim 1 , wherein the concentration of the alcohol is about 10%. 
     
     
         18 - 19 . (canceled) 
     
     
         20 . A method for reducing microbial organisms from a surface comprising contacting the surface with at least one alcohol, at least one antimicrobial agent other than chlorhexidine, and at least one chelator, for an amount of time sufficient to reduce microbial organisms on the surface. 
     
     
         21 . (canceled) 
     
     
         22 . The method of  claim 20 , wherein the contacting is performed for 2 hours or less. 
     
     
         23 . The method of  claim 20 , wherein the contacting is performed for 1 hour or less. 
     
     
         24 . The method of  claim 20 , wherein the contacting is performed for 30 minutes or less. 
     
     
         25 . The method of  claim 20 , wherein the contacting is performed for 15 minutes or less. 
     
     
         26 . (canceled) 
     
     
         27 . The method of  claim 20 , wherein the surface is an oil pipeline, a water pipeline, a fluid pipeline, an ice machine pipe, or a beverage dispensing pipe. 
     
     
         28 . A kit for disinfecting a surface to reduce microorganisms thereon, wherein the kit comprises: (a) the antimicrobial solution of  claim 1 ; or (b) at least one alcohol, at least one antimicrobial agent other than chlorhexidine, and at least one chelator, said components being contained in separate or a single container. 
     
     
         29 - 40 . (canceled) 
     
     
         41 . The solution of  claim 1 , wherein the alcohol is methanol. 
     
     
         42 . The solution of  claim 1 , wherein the alcohol is ethanol or propylene glycol. 
     
     
         43 . The solution of  claim 1 , wherein the chelator is an ethylenediamine chelator. 
     
     
         44 . The method of  claim 20 , wherein the antimicrobial agent is glutaraldehyde. 
     
     
         45 . The method of  claim 20 , wherein the antimicrobial agent is glutaraldehyde. 
     
     
         46 . The kit of  claim 28 , wherein the antimicrobial agent is glutaraldehyde. 
     
     
         47 . The kit of  claim 28 , wherein the alcohol is methanol, ethanol, or propylene glycol. 
     
     
         48 . The kit of  claim 28 , wherein the chelator is an ethylenediamine chelator.