Anti-inflammatory cranberry flavonol extract preparations

Abstract

The present invention is directed to extracts of cranberries ( Vaccinium macrocarpon ) comprising either mixed flavonols that are substantially free of anthocyanins and proanthocyanidins or a purified cranberry flavonol compound, including myricetin-3-β-xylopyranoside, quercetin-3-β-glucoside, quercetin-3-α-arabinopyranoside, 3′-methoxyquercetin-3-α-xylopyranoside, quercetin-3-O-(6″-p-coumaroyl)-β-galactoside, and quercetin-3-O-(6″-benzoyl)-β-galactoside. The present invention also embodies the use of those extracts, as well as extracts comprising the cranberry flavonol compound quercetin-3-α-arabinofuranoside, for the treatment of inflammatory disorders. Pharmaceutical, food, dietary supplement, and cosmetic compositions utilizing the extracts or compounds of the present invention are also recited.

1 . (canceled) 
     
     
         2 . A method for the prevention and/or treatment of an inflammatory condition comprising administering an effective dose of a flavonol composition comprising an extract of cranberry flavonols, the extract being substantially free of anthocyanins and proanthocyanidins, wherein each cranberry flavonol present in the composition may be in the form of a pharmaceutically acceptable salt. 
     
     
         3 . (canceled) 
     
     
         4 . A method for the prevention and/or treatment of an inflammatory condition comprising administering an effective dose of a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a flavonol composition comprising an extract of cranberry flavonols, the extract being substantially free of anthocyanins and proanthocyanidins, wherein each cranberry flavonol present in the composition may be in the form of a pharmaceutically acceptable salt. 
     
     
         5 . (canceled) 
     
     
         6 . A method for the prevention and/or treatment of an inflammatory condition comprising administering an effective dose of a dietary supplement composition comprising a consumable carrier and a flavonol composition comprising an extract of cranberry flavonols, the extract being substantially free of anthocyanins and proanthocyanidins, wherein each cranberry flavonol present in the composition may be in the form of a pharmaceutically acceptable salt. 
     
     
         7 . (canceled) 
     
     
         8 . A method for the prevention and/or treatment of an inflammatory condition comprising administering an effective dose of a food composition comprising a consumable carrier and a flavonol composition comprising an extract of cranberry flavonols, the extract being substantially free of anthocyanins and proanthocyanidins, wherein each cranberry flavonol present in the composition may be in the form of a pharmaceutically acceptable salt. 
     
     
         9 - 23 . (canceled) 
     
     
         24 . A compound having the formula 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof. 
     
     
         25 . A method for the prevention and/or treatment of an inflammatory condition comprising administering an effective dose of the compound of  claim 24 . 
     
     
         26 . A composition comprising a pharmaceutically acceptable carrier and the compound of  claim 24 . 
     
     
         27 . A method for the prevention and/or treatment of an inflammatory condition comprising administering an effective dose of the pharmaceutical composition of  claim 26 . 
     
     
         28 . A dietary supplement composition comprising a consumable carrier and the compound of  claim 24 . 
     
     
         29 . A method for the prevention and/or treatment of an inflammatory condition comprising administering an effective dose of the dietary supplement composition of  claim 28 . 
     
     
         30 . A food composition comprising a consumable carrier and the compound of  claim 24 . 
     
     
         31 . A method for the prevention and/or treatment of an inflammatory condition comprising administering an effective dose of the food composition of  claim 30 . 
     
     
         32 . The food composition of claim,  30  wherein the consumable carrier is a cranberry-containing food product. 
     
     
         33 . The food composition of  claim 32 , wherein the cranberry-containing food product is a dried cranberry, a sweetened and dried cranberry, a powdered cranberry, a flavored fruit piece, a sauce, a jelly, a relish, a juice, a wine or a cranberry juice-containing product. 
     
     
         34 . The food composition of  claim 30 , wherein the consumable carrier is a beverage. 
     
     
         35 . (canceled) 
     
     
         36 . A method for the prevention and/or treatment of an inflammatory condition comprising administering an effective dose of a cosmetic composition comprising a cosmetically acceptable carrier and a flavonol composition comprising an extract of cranberry flavonols, the extract being substantially free of anthocyanins and proanthocyanidins, wherein each cranberry flavonol present in the composition may be in the form of a pharmaceutically acceptable salt. 
     
     
         37 - 38 . (canceled) 
     
     
         39 . A cosmetic composition comprising a cosmetically acceptable carrier and the compound of  claim 24 . 
     
     
         40 . A method for the prevention and/or treatment of an inflammatory condition comprising administering an effective dose of the cosmetic composition of  claim 39 .