US2011190807A1PendingUtilityA1

Remote ischemic conditioning for treatment and prevention of restenosis

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Assignee: HOSPITAL FOR SICK CHILDRENPriority: Feb 1, 2010Filed: Feb 1, 2011Published: Aug 4, 2011
Est. expiryFeb 1, 2030(~3.5 yrs left)· nominal 20-yr term from priority
Inventors:Andrew RedingtonChristopher Caldarone
A61B 2017/00557A61P 9/10A61P 7/02A61H 2201/165A61H 23/04A61H 2205/067A61B 17/1355
40
PatentIndex Score
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Cited by
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References
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Claims

Abstract

The invention provides methods for reducing the incidence and/or severity of restenosis through the use of remote ischemic conditioning.

Claims

exact text as granted — not AI-modified
1 . A method for reducing restenosis in subject comprising
 performing a repeated remote ischemic conditioning (RIC) regimen on a subject having or at risk of developing restenosis, in an amount and a frequency sufficient to reduce the incidence or severity of restenosis.   
     
     
         2 . The method of  claim 1 , wherein restenosis occurs following a medical intervention. 
     
     
         3 . The method of  claim 1 , wherein the repeated RIC regimen comprises more than one RIC regimen performed on a single day. 
     
     
         4 . (canceled) 
     
     
         5 . The method of  claim 1 , wherein the repeated RIC regimen comprises one or more RIC regimens on more than one day. 
     
     
         6 . The method of  claim 5 , wherein the repeated RIC regimen comprises one or more RIC regimens performed on a daily basis for one month. 
     
     
         7 . The method of  claim 5 , wherein the repeated RIC regimen comprises one or more RIC regimens performed every other day for one month. 
     
     
         8 - 9 . (canceled) 
     
     
         10 . The method of  claim 1 , wherein the subject is human. 
     
     
         11 . The method of  claim 1 , wherein the subject will receive a medical intervention. 
     
     
         12 . The method of  claim 11 , wherein the repeated RIC regimen is performed before the medical intervention. 
     
     
         13 . The method of  claim 11 , wherein the repeated RIC regimen is performed during the medical intervention. 
     
     
         14 . The method of  claim 11 , wherein the repeated RIC regimen is performed after the medical intervention. 
     
     
         15 . The method of  claim 11 , wherein the repeated RIC regimen is performed before and after the medical intervention. 
     
     
         16 . The method of  claim 1 , wherein the medical intervention is an intravascular stent placement. 
     
     
         17 - 20 . (canceled) 
     
     
         21 . The method of  claim 11 , wherein the medical intervention is angioplasty. 
     
     
         22 . The method of  claim 11 , wherein the medical intervention is a non-vascular stent placement. 
     
     
         23 . (canceled) 
     
     
         24 . The method of  claim 11 , wherein at least one RIC regimen is performed within 24 hours of the medical intervention. 
     
     
         25 - 26 . (canceled) 
     
     
         27 . The method of  claim 1 , wherein at least one RIC regimen comprises at least four cycles, each cycle comprising supra-systolic pressure and reperfusion. 
     
     
         28 . The method of  claim 1 , wherein at least one RIC regimen comprises more than one cycle comprising 5 minutes of supra-systolic pressure and 5 minutes of reperfusion. 
     
     
         29 . The method of  claim 27 , wherein the supra-systolic pressure is a pressure that is at least 15 mmHg above systolic pressure. 
     
     
         30 . The method of  claim 1 , wherein the repeated RIC regimen is performed at the same site. 
     
     
         31 - 34 . (canceled)

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