Non-specific reaction inhibitor

Abstract

Disclosed is a non-specific reaction inhibitor for use in an immunological measurement, comprising a complex of an antibody or a fragment of the antibody capable of specifically binding to a non-specific reaction factor, and a polymer. The non-specific reaction inhibitor can inhibit a non-specific reaction which may interfere with the accurate detection or quantification of a trace substance in an immunological measurement method.

1 . A non-specific reaction inhibitor for use in an immunological measurement, comprising a complex of an antibody or a fragment of the antibody capable of specifically binding to a non-specific reaction factor, and a polymer. 
     
     
         2 . The non-specific reaction inhibitor according to  claim 1 , wherein the polymer is a compound selected from the group consisting of a polysaccharide, a protein, and an organic high molecular weight polymer. 
     
     
         3 . The non-specific reaction inhibitor according to  claim 1 , wherein the organic high molecular weight polymer is polyethylene glycol. 
     
     
         4 . The non-specific reaction inhibitor according to  claim 1 , wherein the molecular weight of the polymer is 200 Da to 1000 kDa. 
     
     
         5 . The non-specific reaction inhibitor according to  claim 1 , wherein the fragment of the antibody is F(ab) 2 , Fab′, Fab, Fd, an L chain, an H chain or rIgG. 
     
     
         6 . The non-specific reaction inhibitor according to  claim 1 , wherein the bonding of the antibody or a fragment thereof to the polymer is a chemical modification utilizing a thiol, amino, hydroxyl, or carboxyl group, or a biotin-avidin binding. 
     
     
         7 . An immunological measurement method, characterized by using a complex of an antibody or a fragment of the antibody capable of specifically binding to a non-specific reaction factor, and a polymer. 
     
     
         8 . The immunological measurement method according to  claim 7 , wherein the method is a latex agglutination optical measurement method, an enzyme immunoassay, a nephelometric immunoassay, an enzyme-linked immunosorbent assay, an fluoroimmunoassay, or a radioimmunoassay.