US2011183923A1PendingUtilityA1

Peptide antagonists of zonulin and methods for use of the same

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Assignee: UNIV MARYLANDPriority: Aug 3, 1998Filed: Oct 20, 2010Published: Jul 28, 2011
Est. expiryAug 3, 2018(expired)· nominal 20-yr term from priority
Inventors:Alessio Fasano
A61P 37/02A61P 43/00A61P 37/08A61P 35/00A61P 31/00A61P 29/00A61P 1/00A61P 1/04A61P 1/06C07K 7/08C07K 14/4705C07K 7/06A61K 38/00C07K 14/4716
59
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Claims

Abstract

Peptide antagonists of zonulin are disclosed, as well as methods for the use of the same. The peptide antagonists bind to the zonula occludens receptor, yet do not physiologically modulate the opening of mammalian tight junctions.

Claims

exact text as granted — not AI-modified
1 - 17 . (canceled) 
     
     
         18 . A method for inhibiting permeability of the small intestine, comprising:
 administering to the small intestine of a subject in need thereof an effective amount of a peptide, the amino acid sequence of the peptide consisting essentially of SEQ ID NO:15 so as to act as an inhibitor of the paracellular pathway.   
     
     
         19 . The method of  claim 18 , wherein the subject has celiac disease. 
     
     
         20 . The method of  claim 18 , wherein the subject has inflammatory bowel disease. 
     
     
         21 . The method of  claim 18 , wherein the peptide is administered in a gastroresistant tablet. 
     
     
         22 . The method of  claim 18 , wherein the peptide is administered in a gastroresistant capsule. 
     
     
         23 . The method of  claim 22 , wherein the capsule comprises gastroresistant beads. 
     
     
         24 . The method of  claim 18 , wherein the peptide is administered in a liquid oral dosage composition.

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